Meet the Cohort

Elena Aikawa, MD, PhD
Professor, Brigham and Women’s Hospital

Elena Aikawa is professor of medicine at Harvard Medical School and Naoki Miwa Distinguished Chair in Cardiovascular Medicine at Brigham and Women’s Hospital (BWH). She is also co-director of the Center for Interdisciplinary Sciences, founding director of the Heart Valve Translational Research Program, and associate head of section of Cardiovascular Life Sciences at BWH. Aikawa is a passionate advocate for the early imaging and treatment of calcific aortic valve disease. Her research program, which has been continuously supported by NIH funding, focuses on the development of new therapies to prevent, treat, and cure calcific aortic valve stenosis, a disease that currently has no treatment options other than valve replacement. She was at the forefront in the discovery of inflammation-dependent mechanisms of cardiovascular calcification. Her studies contributed to the discovery of calcifying extracellular vesicles (exosomes) as a precursor of microcalcification. She holds editorial positions at the Cardiovascular Research, Circulation Research, Journal of Extracellular Vesicles, PLoS ONE, and Arteriosclerosis Thrombosis and Vascular Biology.

How has mentoring impacted your own career?
Mentoring has made me more inclusive, more patient, more flexible, and more kind. I have become a good listener and better communicator.

Masanori Aikawa, MD, PhD
Professor, Brigham and Women’s Hospital

Masanori Aikawa serves as director of the Center for Interdisciplinary Cardiovascular Sciences (CICS) at Brigham and Women’s Hospital (BWH). His research interests include the pathogenesis of atherosclerosis and metabolic disorders, macrophage biology, and the pro-inflammatory role of dyslipidemia. Aikawa’s ultimate goal is to translate basic research findings into clinical practice through multidisciplinary efforts. His role as founding director of CICS represents this goal, where explorations for new therapeutic targets for cardiometabolic diseases are carried out in transpacific collaboration with Kowa Company, Ltd. a Japanese pharmaceutical company. Aikawa also has a research laboratory in the Center for Excellence in Vascular Biology at BWH, primarily supported by grants from the National Institutes of Health and the American Heart Association, where he studies novel triggering mechanisms of macrophage activation in the contexts of atherosclerosis and metabolic disorders. He completed his clinical training at Juntendo University School of Medicine, in Tokyo, Japan, and began his initial research at the University of Tokyo.

What are you looking forward to as a mentor this year in the program?
I look forward to exchanging experiences and thoughts between my mentees and myself as a mentor. Such two-way traffic is important for both sides. It gives mentees opportunities to systematically think of their strategies and future directions. It also helps a mentor further develop her/his skills as an efficient educator.

Manoj Duraisingh, PhD, MSc
Professor, Harvard T.H. Chan School of Public Health

Manoj Duraisingh is the John LaPorte Given Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health (HSPH) and an associate member of the Broad Institute of MIT and Harvard. His research program at HSPH focuses on elucidating the biology of host–parasite interactions in malaria. His laboratory develops and applies advanced technologies to study Plasmodium spp. and red blood cells, with a particular emphasis on molecular genetic approaches to investigate critical interactions between human red blood cells and malaria parasites, and to inform the development of therapeutic interventions. Significant efforts are also focused on establishing in vitro blood-stage culture and genetic systems to study other human Plasmodium parasites, including P. vivax and P. knowlesi, as well as their transmission. New initiatives include the development of red blood cell production platforms, and the engineering of red blood cells using synthetic biology. Duraisingh is also engaged in collaborative studies in malaria-endemic areas, particularly in India, where he has focused on the biology and pathogenesis of P. vivax and P. falciparum parasites in natural populations. Duraisingh obtained a BA in biochemistry from the University of Oxford and MSc and PhD degrees in molecular parasitology from the London School of Hygiene and Tropical Medicine. He additionally pursued postdoctoral research in molecular parasitology at the Walter and Eliza Hall Institute in Melbourne, Australia.

How has mentoring impacted your own career?
My path as a professional scientist in academia has been a bit of a roller-coaster ride. Mentors along the way, both formal and informal, have played a great part in helping me to understand and navigate the system, its expectations and opportunities, and to provide a source of inspiration and comfort.

Daniel B. Kramer, MD, MPH
Associate Professor, Beth Israel Deaconess Medical Center

Daniel Kramer is an associate professor of medicine at Harvard Medical School, where he also serves as faculty for the Center for Bioethics and affiliated faculty for the Brigham and Women’s Hospital Program on Regulation, Therapeutics, and Law. Additionally, he is a member of the Cardiac Electrophysiology Service at Beth Israel Deaconess Medical Center (BIDMC), where he directs the Pacemaker and ICD Service. He is a founding member and section head of electrophysiology and digital health at the Richard and Susan Smith Center for Outcomes Research. Kramer’s research focuses on ethics, policy, and clinical outcomes related to the use of cardiac devices, with past and ongoing funding support from the Paul Beeson Scholars Program, the Greenwall Faculty Scholars Program in Bioethics, the National Institutes of Health, Pew Charitable Trusts, the Patient-Centered Outcomes Research Institute, and ARPA-H. Kramer graduated Phi Beta Kappa with a degree in philosophy from Brown University and received his MD from Harvard Medical School and MPH from the Harvard T.H. Chan School of Public Health. He completed internal medicine training at Massachusetts General Hospital and fellowships in cardiovascular disease and clinical cardiac electrophysiology at BIDMC, as well as the Medical Device Fellowship Program with the FDA.

How has mentoring impacted your own career?
I have benefited tremendously from both formal and informal mentors across multiple disciplines. My mentors have shaped every aspect of my scholarly work and professional practice, and continue to support me even after my transition to independent funding.

William Mair, PhD
Professor, Harvard T.H. Chan School of Public Health

William Mair is a professor of molecular metabolism, and director of the Harvard T.H. Chan Healthy Aging Initiative. The Mair lab studies mechanisms that mitigate the risks of aging, with a focus on metabolic flexibility and how changes to food intake can impact the aging process. The lab studies how nutrient and energy sensors in cells become dysfunctional with age, leading to metabolic inflexibility and acerated aging. Mair’s work aims to develop therapeutics that maintain healthy metabolic function, thereby enabling our bodies to process the food we eat effectively as we age and prolonging healthy aging. His lab is driven by the central questions: Why are we more likely to get chronic diseases when we are old than when we are young? What goes wrong in cells and tissues to increase overall disease risk, is this decline inevitable, or can we reverse it to bring healthy years to the elderly? Mair received his BSc in genetics and PhD in biology from University College London, and completed his postdoctoral training at the Salk Institute for Biological Studies in La Jolla, CA. He is an elected member of the Academy for Health & Lifespan Research, and has won numerous awards for his work on aging and geroscience, including the American Federation Breakthrough in Gerontology Award, the Glenn Medical Foundation for Medical Research Scholar Award, and the Ellison Medical Foundation New Scholar in Aging Research Award.

How has mentoring impacted your own career?
I have had excellent mentors, and not so excellent mentors, and both have had a profound effect on my career in positive and negative ways. Mentoring is a learned science and one that, if done well, can transform careers. I know that without many champions and mentors I would have given up a long time ago, and I see paying that forward as one of the best parts of my job and the most rewarding.

Josiemer Mattei, PhD, MPH, FAHA
Professor, Harvard T.H. Chan School of Public Health

Josiemer Mattei is the Donald and Sue Pritzker Associate Professor of Nutrition and Director of the Nutrition Research, Culture, and Equity (NURTURE) Program at the Department of Nutrition at the Harvard T.H. Chan School of Public Health. She investigates dietary, metabolic, and psychosocial determinants of cardiometabolic conditions, as a framework to elucidate and reduce health disparities among racial/ethnic minoritized groups and underserved populations. Her work applies an equity-centered transdisciplinary lens using mixed-methods, observational studies, and dietary trials, through projects in the United States, Puerto Rico, and Latin America, including the PROSPECT cohort, the PRECISION clinical trial, and the WELCOME community intervention, and long-standing collaborations with the Boston Puerto Rican Health Study and the Hispanic Community Health Study/Study on Latinos. She promotes evidence-based policy and programs for better access to healthy, accessible foods and cardiometabolic health aligned with traditional cultural values and environmental sustainability. She has received multiple accolades for her research, mentoring, and public health work.

How has mentoring impacted your own career?
If you’re lost, you check for directions. If you’re drowning, you need a lifesaver. If you’re happy and proud, you want to climb to the top of a mountain and shout it loud for the world to hear. That’s what my mentors have been to me: a map and compass, a lifesaver, and a mountain bolstering me and my work.

Murray Mittleman, MD, DrPH
Professor, Harvard T.H. Chan School of Public Health

Murray Mittleman is a physician and epidemiologist. He is a professor of epidemiology and the faculty director and chair of the Master of Public Health Program at the Harvard T.H. Chan School of Public Health. He also serves as MPI on two T32 research training programs—one in cardiovascular research and another in resuscitation science—both based at Beth Israel Deaconess Medical Center (BIDMC). Mittleman has expertise in designing observational etiologic studies and his research focuses on developing and applying epidemiologic methods. One of his major achievements was co-developing the case-crossover design. His applied research mainly aims to identify and understand physical, psychosocial, and chemical stressors—including cannabis—that may trigger acute cardiovascular events and influence long-term prognosis. Mittleman’s clinical work focuses on primary and secondary prevention of cardiovascular disease at the Cardiovascular Health and Lipid Center and the Advanced Hypertension Center; both located at BIDMC.

How has mentoring impacted your own career?
Working with great mentors has inspired me to pursue research questions that I find intriguing and fulfilling to study.

Marsha A. Moses, PhD
Professor, Boston Children’s Hospital

Marsha Moses is the Julia Dyckman Andrus Professor at Harvard Medical School and the director of the Vascular Biology Program at Boston Children’s Hospital (BCH). She is internationally recognized for her significant contributions to our understanding of the biochemical and molecular mechanisms that underlie the regulation of tumor development and progression. Moses and her laboratory have discovered several inhibitors of these processes that function at both the transcriptional and translational level, some of which are being investigated for potential clinical use. She and her team have engineered novel, actively targeted, precision nanomedicines for the treatment of human cancers and their metastases. Named a pioneer in the field of biomarker medicine by the Journal of the National Cancer Institute, Moses has established a Proteomics Initiative in the Vascular Biology Program and has utilized its resources to discover and validate a number of noninvasive cancer biomarkers that can predict disease status and stage in cancer patients and that are sensitive and specific biomarkers of disease progression and therapeutic efficacy of cancer drugs. Some of these biomarkers are currently being utilized clinically and others are being tested in multiple clinical trials. Moses received a PhD in biochemistry from Boston University and completed a National Institutes of Health postdoctoral fellowship at BCH and at the Massachusetts Institute of Technology. She is the recipient of many NIH and foundation grants, as well as numerous awards and honors.

How has mentoring impacted your own career?
Mentoring aspiring young scientists and clinicians has been a priority of mine throughout my career. With that said, I have no doubt that I have learned as much from my mentees as they have from me. It continues to be a lesson in perseverance, diligence, and generosity of spirit.

Andrew Onderdonk, PhD
Professor, Brigham and Women’s Hospital

Andrew Onderdonk recently stepped down as director of clinical microbiology at Brigham and Women’s Hospital. He now works part-time teaching residents and mentoring young scientists. He has a lifelong interest in the role of microorganisms in human health and disease. He continues to collaborate with a number of investigators within Harvard University and its affiliates on various aspects of the human microbiome.

What are you looking forward to as a mentor this year in the program?
Helping our young scientists recognize and use all of the resources available to them. By sharing my experiences with them, I hope to provide answers to some of their questions about a scientific career path.

Paola Pedrelli, PhD
Associate Professor, Massachusetts General Hospital

Paola Pedrelli is associate director of the Depression Clinical Research Program at Massachusetts General Hospital and an associate professor of psychiatry at Harvard Medical School. She is a leading scientist in the development of digital tools for the long-term monitoring of depression, leveraging artificial intelligence and wearable and mobile sensors. Her commitment to improving clinical care for depression drives her research into innovative treatment methods. She has developed several face-to-face cognitive behavioral therapy approaches for depression, both in isolation and in conjunction with heavy episodic drinking. Additionally, she has conducted clinical trials on novel digital health interventions for depression. More recently, Pedrelli’s work has centered on investigating the effectiveness of ketamine-based treatments for depression and suicidal thoughts and behaviors, as well as the underlying mechanisms of these conditions. Her research has been supported by the NIH and DARPA, and various foundations and industry partners. Pedrelli has been invited to speak at national and international scientific meetings and has been featured in numerous media outlets. She has authored more than 70 peer-reviewed publications and chapters.

How has mentoring impacted your own career?
Mentoring has been instrumental in shaping my career, providing invaluable guidance and numerous opportunities for growth. Through the support of my mentors, I have navigated complex challenges and gained insights that have significantly enhanced my professional development. Recognizing the profound impact mentorship has had on my journey, I am committed to offering the same support and opportunities to others. By mentoring, I aim to empower individuals to achieve their potential and succeed in their careers. This reciprocal exchange of knowledge and experience enriches both the mentor and mentee, fostering a collaborative and supportive professional community.

Melissa Putman, MD, MMSc
Associate Professor, Massachusetts General Hospital

Melissa Putman is an adult and pediatric endocrinologist. She is an internationally recognized leader in the field of cystic fibrosis (CF) endocrinology and in the investigation of diabetes technology in understudied and high-risk diabetes populations. Putman serves as the director of the Massachusetts General Hospital (MGH) Diabetes Research Center, which oversees ground breaking clinical research in the field of diabetes. She is supported by grants from the NIH and Cystic Fibrosis Foundation. Her clinical expertise has fueled her research as a clinical investigator. As a junior faculty member, Putman developed the CF Endocrine Program within the (MGH) and Boston Children’s Hospital (BCH) CF Centers. In caring for people with CF, she has identified important research questions, created innovative clinical research protocols, and developed an international reputation as an expert in CF endocrine complications, including CF related diabetes (CFRD) and CF related bone disease. More recently, Putman has expanded her research to encompass novel interventions in the management of Type 1 and Type 2 Diabetes, with a focus on high risk and understudied populations. She has been nominated for an HMS Mentoring Award for the past three years and was the inaugural awardee of the annual Endocrine Attending of the Year by the endocrine fellows at BCH for excellence in teaching. She also received the 2020 J.F.P Ullman Award for Exceptional Mentorship from the BCH Postdoc Association. Putman currently servs as mentor for multiple junior faculty members at MGH and BCH.

What are you looking forward to as a mentor this year in the program?
Being a mentor has been one of the favorite parts of my job. It is so rewarding to be able to work with motivated junior investigators to help them reach their goals. I look forward to meeting new mentees in different fields of study and creating new mentorship networks at Harvard Medical School.

Yakeel T. Quiroz, PhD
Associate Professor, Massachusetts General Hospital

Yakeel Quiroz-Gaviria is associate professor in the Departments of Psychiatry and Neurology at Harvard Medical School and Massachusetts General Hospital (MGH). She is also the director of the MGH Familial Dementia Neuroimaging Lab and the Multicultural Alzheimer’s Prevention Program. Additionally, she serves as director of the MGH Multicultural Assessment and Research Center and the MGH postdoctoral and predoctoral training programs in multicultural neuropsychology. Her research interests include brain imaging, genomics, early detection and preclinical biomarkers of Alzheimer’s disease and other dementias. She is the principal investigator of two NIH NIA R01 grants and co-investigator of both the Harvard Aging Brain Study and the Alzheimer’s Clinical Trials Consortium. Quiroz-Gaviria’s work has provided evidence of brain abnormalities in cognitively intact individuals at genetic risk for Alzheimer’s disease, decades before their clinical onset. Her findings have helped the field to re-conceptualize Alzheimer as a sequence of changes that begins decades before cognitive decline. She earned her master’s degree in cognitive neuroscience and PhD in clinical psychology from Boston University.

How has mentoring impacted your own career?
I believe that mentoring is a bi-directional process. My mentees have contributed to my personal and scientific growth. I encourage them to provide continued feedback and do my best to integrate their recommendations.

Frederick Schoen, MD, PhD
Professor, Harvard Medical School & Brigham and Women’s Hospital

Frederick Schoen is professor of pathology and health sciences and technology at Harvard Medical School (HMS) and a cardiovascular pathologist. He was the executive vice‐chairman in the Department of Pathology at Brigham and Women’s Hospital (BWH) for more than 20 years, and more recently vice chair for faculty affairs. He received a BSE (materials and metallurgical engineering) from the University of Michigan, his PhD in materials science from Cornell University, and his MD from the University of Miami School of Medicine. Schoen’s original work broadly comprises biomaterials, cardiovascular pathology, and interventional/surgical pathology. His most fulfilling research focuses on native heart valve biology and valve replacement devices, calcification mechanisms in bioprosthetic heart valves and anti-calcification therapies, and tissue engineering. Schoen has led forward-thinking education and mentoring in healthcare innovation and translational biomedical engineering and faculty development activities at BWH and collaborating institutions (HMS, Harvard Catalyst, and the Harvard-MIT Division of Health Sciences and Technology).

How has mentoring impacted your own career?
I have benefitted greatly from both developmental and skills mentoring, and by having excellent professional role models. As I migrated from a predominantly engineering to a medical focus, these inputs were particularly important. For many years I have gained great satisfaction from working with my department colleagues to document their accomplishments and shepherd their promotions through the Harvard Medical School promotions process. As time progressed, I became interested in sharing what I have learned by developing programs based at BWH, HMS, and Harvard Catalyst to help young professionals optimize their mentoring relationships and to help established academics develop mentoring skills.

Ludy C. Shih, MD, MMSc
Associate Professor, Beth Israel Deaconess Medical Center

Ludy Shih is a clinical investigator in Parkinson’s disease (PD) and essential tremor. She also studies parkinsonism and aging at the Framingham Heart Study. She additionally serves as associate editor at Annals of Clinical and Translational Neurology and president of the American Society of Experimental Neurotherapeutics. She previously worked at Biogen and Vertex Pharmaceuticals, designing global phase 1/2 clinical studies for PD and genetic neurologic diseases. She received her MD from the University of California Los Angeles and completed an internship, neurology residency, and movement disorders fellowship at Beth Israel Deaconess Medical Center. She also received her master’s in clinical investigation through the Harvard-MIT Health Sciences and Technology Clinical Investigator Training Program.

What are you looking forward to as a mentor this year in the program?
I’m looking forward to forming new relationships and seeing the uniqueness each person brings to our immense talent pool. I hope to be a sounding board and provide useful coaching to help people identify what matters most to them.

Veronique VanderHorst, MD, PhD
Associate Professor, Beth Israel Deaconess Medical Center

Veronique VanderHorst is associate professor of neurology at Harvard Medical School and staff physician in the Parkinson’s Disease and Movement Disorders Center at Beth Israel Deaconess Medical Center (BIDMC). In her current research, she integrates her clinical and neuro-anatomical/physiological experience to study connections and functions of brainstem and spinal circuitries that control muscle tone, posture, breathing and walking, in normal conditions and in disease models of dystonias, parkinsonism, and sleep apnea. She makes use of state-of-the-art chemogenetic and optogenetic technologies in combination with tract tracing and electrophysiology in animal models, while translational efforts include collaborative clinical-pathological and clinical studies. A major focus in her work is on translatable outcome measures. Her work has been funded by the National Institutes of Health, the Bachmann Strauss Dystonia and Parkinson Foundation, Center for Mind Brain Restoration, and the Goldberg Foundation. She earned her PhD in neuroscience from the University of Groningen in the Netherlands, was awarded a fellowship from the Royal Netherlands Academy of Arts and Sciences and completed a neurology residency training and movement disorders fellowship at BIDMC.

What are you looking forward to as a mentor this year in the program?
I’m looking forward to sharing my career adventures with the mentees. While a science background is often very different, we all wrestle with the same central questions related to career paths and work-balance decisions.