Seminar: BWH Oncology Series
This BWH Oncology Seminar will be presented by Jann N. Sarkaria, MD, the prominent professor of radiation oncology leading the Translational Neuro-oncology laboratory in Mayo Clinic located in Rochester, MN.
Dr. Sarkaria’s Focus areas:
- Drug penetration across the blood-brain barrier – The blood-brain barrier can be a major obstacle to delivering effective therapies for patients with brain tumors. Thus, a major focus of the laboratory is defining which drugs have adequate penetration into brain tumors and testing novel delivery methods to enhance drug accumulation into brain tumors.
- Patient-derived xenograft models – The laboratory has an extensive collection of GBM and brain metastases patient-derived xenograft models with extensive characterization by various next-generation sequencing platforms as well as significant phenotypic characterization. These models are used extensively in the laboratory for translational studies.
- Sarkaria’s laboratory aims to facilitate translation of novel findings into clinical trials for patients with GBM.