Biostatistics journal club: A Glimpse of Statistical Methods for Vaccine Evaluation

Hang Lee, PhD, Massachusetts General Hospital, will lead discussion on key statistical issues and related statistical methods arising in all phases of vaccine development. As an overview, a review paper by Heyse and Chan (2016) will be discussed first, and then a recently published work by Lin, Zeng, and Gilbert (2021) regarding the strategy to evaluate the long-term efficacy/duration of protection of COVID-19 vaccines. Registration required.

Required reading:

Joseph Heyes & Ivan Chan. Review of Statistical Innovations in Trials Supporting Vaccine Clinical Development, Statistics in Biopharmaceutical Research, 2016, 8:1, 128-142.

Dan-Yu Lin, Donglin Zeng, and Peter Gilbert. Evaluating the Long-term Efficacy of Coronavirus Disease 2019 (COVID-19) Vaccines, Clinical Infectious Diseases, 2021 Mar 10:ciab226. doi: 10.1093/cid/ciab226. Online ahead of print. PMID: 33693529. See PDF of journal club article.