Isaac Kohane is faculty lead of Biomedical Informatics at Harvard Catalyst, the inaugural chair of the Department of Biomedical Informatics and the Marion V. Nelson Professor of Biomedical Informatics at Harvard Medical School. In his work, Kohane develops and applies computational techniques to address disease at multiple scales, from whole healthcare systems as “living laboratories” to the functional genomics of neurodevelopment with a focus on autism. Kohane’s i2b2 project is currently deployed internationally to more than 120 major academic health centers to drive discovery research in disease and pharmacovigilance (including providing evidence on drugs which ultimately contributed to “boxed warning” by the FDA). Kohane has published several hundred papers in the medical literature and authored a widely-used book on microarrays for an integrative genomics. He is a member of the Institute of Medicine and the American Society for Clinical Investigation.