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COVID-19 Research Resources
A curated list of research resources around guidelines, policies, and procedures related to COVID-1, drawn from Harvard University, affiliated academic healthcare centers, and government funding agencies

COVID-19 Research Resources
A curated list of research resources around guidelines, policies, and procedures related to COVID-1, drawn from Harvard University, affiliated academic healthcare centers, and government funding agencies

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Biostatistics journal club: Novel Mediation Analysis of Human Plasma Proteome and Metabolome Reveals Mediators of Improved Glycemia After Gastric Bypass Surgery – March 11

Wednesday, March 11, 2020
1:00 pm – 2:00 pm

Novel Mediation Analysis of Human Plasma Proteome and Metabolome Reveals Mediators of Improved Glycemia After Gastric Bypass Surgery

Jonathan Dreyfuss PhD; Instructor in Medicine, Harvard Medical School; Associate Director of Bioinformatics and Biostatistics Core, Joslin Diabetes Center

Abstract
Molecular mechanisms by which Roux-en-Y gastric bypass (RYGB) improves glycemic control and metabolism in type 2 diabetes (T2D) remain incompletely understood. In the SLIMM-T2D trial, participants with T2D were randomized to RYGB or nonsurgical management and their fasting plasma proteome and metabolome were analyzed for up to three years. To identify analytes that mediate improvement in outcomes, we developed a high-throughput mediation analysis method (Hitman), which is significantly more powerful than existing methods.

Related Readinghttps://www.biorxiv.org/content/10.1101/817494v1

Presentation slides [PDF]

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