PCORI Funding

Promoting Healthy Children and Youth

The Promoting Healthy Children and Youth Funding Announcement (PFA) is soliciting applications for patient-centered comparative clinical effectiveness research (CER) studies that focus on interventions that improve patient-centered outcomes in children and youth, 0-24 years of age. To increase evidence that addresses meaningful decisional dilemmas faced by patients, families, clinicians and other health and healthcare community members, this opportunity aims to fund CER studies that compare interventions across the care continuum to improve patient-centered outcomes in children and youth. Applications may propose comparative effectiveness studies of prevention, screening, diagnostic, treatment and management approaches, and pharmacologic, non-pharmacologic and/or combination therapies, as appropriate. For this funding announcement, applicants may request coverage of patient care costs (including medical products, procedures, and care services) for potential funding by PCORI.

PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs), although applicants are not limited to these areas:

• Prevention and treatment of obesity
• Addressing social determinants of health/social needs to improve health outcomes
• Targeted prevention of substance misuse through identified risk factors

Highlights

• Up to $100 million in total available funding
• Up to $12 million direct costs available per application
• Maximal project period: 5 years
• Applications open September 4
• Town Hall: September 18
• Letters of Intent due October 1

How to Apply

To apply for this funding opportunity, there are four steps you must follow.

1. Read the full funding announcement, available online on September 4, 2024.
2. Follow the process outlined in the submission instructions.
3. Submit a Letter of Intent using the template on the application page.
4. Submit an application (if invited).

Important dates

September 4 – Applications open
September 18 – Town Hall
October 1 – Letters of Intent due
October 29 – Notice of invitation to submit full application
January 14, 2025 – Applications due
April 2025 – Merit review
July 2025 – Awards announced
November 2025 – Earliest start date

PCORI Special Office Hours

Potential applicants can also request an opportunity to speak with PCORI staff for more complex questions during virtual “office hours.” Submit your project information and questions on the website.

Harvard Catalyst PCORI Consultation

For more information or to request a brief consultation, please contact the Harvard Catalyst PCORI Funding Specialist, Leslie MacGregor: Leslie_MacGregor@hms.harvard.edu