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PCORI Funding

Open Opportunities: Patient-Centered Outcomes Research Institute (PCORI)

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Home > PCORI Funding > Managing Pain – Cycle 1 – 2025

Managing Pain

New Patient-Centered Outcomes Research Institute (PCORI) funding opportunity: Up to $12 million in direct costs for studies with a duration of up to five years.

Studies should:

  • Focus on interventions that improve patient-centered outcomes in patients with acute or chronic pain
  • Include evidence-based, impactful, patient-centered outcomes as indicated by patients, families, and caregivers (particularly those with lived experience) from the population of interest, as well as relevant members of the broader health and healthcare community
  • Examine diverse populations with an overall sample size that will allow precision in the estimation of hypothesized effect sizes and, as appropriate, analysis of heterogeneity of treatment effect

PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs), although applicants are not limited to these areas:

  • Urogynecological and pelvic pain
  • Pain in individuals living with limitations in cognitive functioning
  • Pain in individuals living with sickle cell disease
  • Neuropathic pain

For this funding announcement, applicants may request coverage of patient care costs (including medical products, procedures, and care services) for potential funding.

Applications may propose patient, healthcare provider, and/or systems-level CER studies addressing acute or chronic pain across the care continuum in any clinical context.

Highlights

  • Up to $100 million in total available funding
  • Up to $12 million direct costs available per application
  • Maximum project period: 5 years
  • Town Hall: October 30, 2024 (view recording)
  • Application opens: December 3, 2024
  • Letters of Intent due: January 14, 2025

How to Apply

To apply for this funding opportunity, there are four steps you must follow.

  1. Read the full funding announcement, available online on December 3, 2024.
  2. Follow the process outlined in the submission instructions.
  3. Submit a Letter of Intent using the template on the application page.
  4. Submit an application (if invited).

Important dates

October 30, 2024 – Town Hall – view recording
December 3, 2024 – Application opens
January 14, 2025 – Letters of Intent due
May 6, 2025 – Applications due
July 2025 – Merit review
November 2025 – Awards announced
March 2026 – Earliest start date

PCORI consultation about proposed research

PCORI encourages all investigators interested in applying to use their inquiry form to submit questions and request to speak with a PCORI program officer.

Harvard Catalyst PCORI consultation

For more information or to request a brief consultation, please contact the Harvard Catalyst PCORI Funding Specialist, Leslie MacGregor: Leslie_MacGregor@hms.harvard.edu