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PCORI Funding

Open Opportunities: Patient-Centered Outcomes Research Institute (PCORI)

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Home > PCORI Funding > Intellectual and Developmental Disabilities – Cycle 2 – 2025

Intellectual and Developmental Disabilities

New Patient-Centered Outcomes Research Institute (PCORI) funding opportunity: Up to $12 million in direct costs for studies comparing two or more approaches for prevention, diagnosis, treatment or care delivery that focus on people with intellectual and developmental disabilities (IDDs). The project duration can be up to five years.

Studies should:

  • Address a critical clinical or care delivery problem
  • Have well-documented evidence of efficacy and/or widespread use, as demonstrated by prior research, systematic reviews, and/or clinical guidelines
  • Include evidence-based, impactful, patient-centered outcomes as indicated by patients, families, and caregivers (particularly those with lived experience) from the population of interest, as well as relevant members of the broader health and healthcare community
  • Examine diverse populations with an overall sample size that will allow precision in the estimation of hypothesized effect sizes and, as appropriate, analysis of heterogeneity of treatment effect

PCORI is particularly interested in submissions that address the following Special Areas of Emphasis (SAEs), although applicants are not limited to these areas:

  • Oral health
  • Gastrointestinal health
  • Improving care delivery and addressing ableism

For this funding announcement, applicants may request coverage of patient care costs (including medical products, procedures, and care services) for potential funding.

Highlights

  • Up to $120 million in total available funding
  • Up to  $12 million direct costs available per application
  • Maximum project period: 5 years
  • April 1 – Application opens
  • April 7 – Town Hall
  • May 13 – Letters of Intent due

How to Apply

To apply for this funding opportunity, there are four steps you must follow.

  1. Read the full funding announcement, available online.
  2. Follow the process outlined in the submission instructions.
  3. Submit a Letter of Intent using the template on the application page.
  4. Submit an application (if invited).

Important dates

April 1 – Application opens
April 7 – Town Hall
May 13 – Letters of Intent due
June 10 – Letter of intent status notification
September 3 – Applications due
November – Merit review
March 2026 – Awards announced
July 2026 – Earliest start date

PCORI consultation about proposed research

PCORI encourages all investigators interested in applying to use their inquiry form to submit questions and request to speak with a PCORI program officer.

Harvard Catalyst PCORI consultation

For more information or to request a brief consultation, please contact the Harvard Catalyst PCORI Funding Specialist, Leslie MacGregor: Leslie_MacGregor@hms.harvard.edu