Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum – Cycle 3

The Patient-Centered Outcomes Research Institute (PCORI) has recently announced a funding opportunity that will provide up to $5 million in direct costs for comparative clinical effectiveness research (CER) projects up to five years long that focus on optimizing physical and mental functioning for community-dwelling older adults and their caregivers.

Funding Opportunity Details

The Healthy Aging Targeted PCORI Funding Announcement will solicit applications for CER studies that focus on different phases of the aging continuum and aim to achieve one or more of the following four goals:

  • maintaining function and independence
  • facilitating chronic disease management
  • supporting individuals with significant functional impairment
  • reducing caregiving burden and improving quality of life

PCORI especially encourages applications examining interventions that emphasize caregiver needs and models of care that integrate the formal health care system with community-based services. We further encourage applications focused on populations benefiting from a health equity approach, including those that are underserved, underrepresented, or historically excluded. Interventions may be delivered in primary and specialty care clinics and home and community-based settings (e.g., assisted living, senior housing, and retirement communities; adult day care programs). Applications primarily evaluating pharmacologic interventions will be considered non-responsive to this reissuance. Applicants are strongly encouraged to propose individual, or cluster randomized controlled trials; however, well-specified natural experiments will also be considered.

For more information or to request a brief consultation, please contact Leslie MacGregor, PCORI Funding Specialist:


Total allocated for this PFA: Up to $25 million in total costs
Total direct funding: up to $5 million

Maximum project duration

Five years

Important dates

September 7 – Applications open
September 20 – Town Hall
October 4 – Letters of Intent due
January 10 – Applications due
March 2023 – Merit review
July 2023 – Awards announced
November 2023 – Earliest start date