The Patient-Centered Outcomes Research Institute (PCORI) has recently announced a funding opportunity that will provide up to $10 million in direct costs for studies up to five years long that compare the effectiveness of interventions for one or more of prevention, early detection, and treatment of delirium in older adults. PCORI is particularly interested in multisite randomized controlled trials. Observational studies may be responsive if the choice of observational design is well justified and the proposed methods are robust. Applicants can propose to compare the effectiveness of single and multicomponent nonpharmacologic interventions, pharmacological, and/or nonpharmacological combination interventions.

For more information or to request a brief consultation, please contact Leslie MacGregor, PCORI Funding Specialist:

Question of interest

What is the comparative effectiveness of interventions for the prevention, early detection, and treatment of delirium in older adults?


Older adults


For prevention: head-to-head comparisons of single and multicomponent nonpharmacologic interventions; evidence for screening tools in different healthcare settings; effective implementation and uptake of interventions; and pharmacologic and nonpharmacologic interventions for delirium treatment


Total allocated for this PFA: Up to $30 million in total costs
Total direct funding: up to $5 million for small studies, and up to $10 million for large studies

Maximum project duration

Five years

Important dates

January 11 – Applications open
January 24 – Town Hall
February 8 – Letters of Intent due
May 3 – Applications due
July 2022 – Merit review
December 2022 – Awards announced
March 2023 – Earliest start date