Resident memory T cells (TRM) are specialized, non-circulating immune cells that form in peripheral tissues following antigen exposure. They accumulate in barrier tissues like the skin, where they provide rapid defense against previously encountered pathogens.

While TRM cells are essential for protective immune responses against infections and cancer, their dysregulation or activation against self-antigens can lead to chronic inflammatory and autoimmune conditions such as psoriasis, vitiligo, and contact dermatitis.

The Montagna Symposium will explore TRM roles in various contexts—including skin diseases, cancer immunity, antiviral defense, and drug hypersensitivity—while also addressing their tissue niches, epigenetic regulation, and implications for vaccine development. The symposium aims to foster interdisciplinary collaboration, translate research into clinical practice, and support the next generation of scientists and clinicians.