Grand rounds: Outcomes Truncated by Death in Randomized Trials

Join us for IMPACT Grand Rounds with Michael Harhay, PhD, MPH, who will be presenting on the “Outcomes truncated by death in randomized trials.”

Michael Harhay, PhD, MPH, leads a research program that develops statistical methods, study designs, and outcome measures to improve studies for patients with critical and severe illnesses. As director of the NIH and PCORI-funded Clinical Trials Methods and Outcomes Lab at the University of Pennsylvania’s Palliative and Advanced Illness Research Center, his team is particularly focused on developing and using causal inference and Bayesian statistical methods to better design and analyze pragmatic and cluster-randomized trials for these patient populations. He has contributed to a wide range of trial methodology areas, including informatively missing or truncated data, estimand refinement, Bayesian trial applications, small-sample corrections, and making the best use of baseline covariate information. In 2022, he joined the Penn Medicine Nudge Unit as the director of statistical evaluation, where he applies these methods to studies in Penn’s health system. Harhay currently serves as a deputy editor of the American Journal of Respiratory and Critical Care Medicine and an associate editor of the International Journal of Epidemiology. In 2023, he was named an Honorary Research Fellow in the MRC Clinical Trials Unit at University College London.