Biostatistics short course: Some Key Concepts in Design and Analysis of Early Development Clinical Trials – 1/15/2019
Led by Steven Piantadosi, MD, PhD, associate senior biostatistician, surgical oncology, Brigham and Women’s Hospital, this course will cover basic principles underlying translational trials and dose-finding methods. The course will discuss the role of uncertainty in the design and interpretation of these trials, the use of the continual reassessment method (CRM) for dose finding, and a generalization of the CRM that relaxes most of the required assumptions underlying the cytotoxic model. A mid-day interlude will discuss some of the historic evolution in clinical trials. After the session, participants have the option to attend a lecture on late developmental failures and pipeline optimization.