Biostatistics Journal Club: A Randomized Trial Estimand and Estimator Example

The International Conference on Harmonisation finalized an estimand framework for randomized trials that was adopted by regulatory bodies worldwide. The framework introduced five strategies for handling post-randomization events. Linda Harrison, PhD, Harvard T.H. Chan School of Public Health, will describe an illustrative example to elucidate the difference between these five strategies and provide an estimation technique for each. Additional insight will be provided by defining situations where certain estimands are equal.

Required Reading:

An Example to Illustrate Randomized Trial Estimands and Estimators (PDF)

Speaker:

Linda Harrison, PhD, Senior Research Scientist
Biostatistics, Harvard T.H. Chan School of Public Health