Training and tools for researchers like you. Pathfinder

Overview

Clinical and translational research is characterized by a spectrum of activities where critical insights are passed between research modalities so that biomedical discoveries can lead to tangible improvements in human health. Explore the videos and interactive diagram to learn more.

Understanding the Spectrum of Translational Research

Clinical & Translational Research Through the Diabetes Lens

Clinical and Translational Research Spectrum

Basic Scientific Discovery
T1
Clinical Insights
T2
Implications for Practice
T3
Implications for Population Health
T4
Improved Global Health
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  • Community-Based Participatory Research (CBPR)
  • Cost Effectiveness/Comparative Effectiveness
  • Health Disparities
  • Public Policy
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  • Observational Studies
  • Personalized Medicine
  • Guideline Development
  • Systematic Reviews/Meta-Analyses
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Examples include:

  • Human Physiology
  • First in Humans (FIH) (healthy volunteers)
  • Proof of Concept (POC)
  • Phase 1 Clinical Trials

Examples include:

  • Phase 2 Clinical Trials
  • Phase 3 Clinical Trials

Examples include:

  • Phase 4 Clinical Trials
  • Health Services Research
    • Dissemination
    • Communication
    • Implementation
  • Clinical Outcomes Research

Examples include:

  • Population-level Outcome Studies
  • Social Determinants of Health

References:

Pathfinder is based on material contained in the following three journal references.

Sung NS, Crowley WF Jr, Genel M, Salber P, Sandy L, Sherwood LM, et al. Central challenges facing the national clinical research enterprise. JAMA. 2003 Mar 12;289(10):1278-87. PubMed ID: 12633190

Westfall JM, Mold J, Fagnan L. Practice-based research - "Blue Highways" on the NIH roadmap. JAMA. 2007 Jan 24;297(4):403-6. PubMed ID: 17244837

Szilagyi PG. Translational research and pediatrics. Acad Pediatr. 2009 Mar-Apr;9(2):71-80. PubMed ID: 19329097