A 35-week online course on the principles and methods of biostatistics. Certificate in Applied Biostatistics - Online

Course Details and Preparation

Course Details

The curriculum includes the following units:

  • Unit 1: Introduction to biostatistics (7 weeks)
    • Lecture topics: What is biostatistics?, Types of data/data displays, Probability/Central limit theorem/confidence intervals, Hypothesis testing, ANOVA, Nonparametrics, Analysis of proportions, Linear regression
  • Unit 2: Study design and statistical communication (7 weeks)
    • Lecture topics: Study design, Power and sample size, Grant writing, Statistical communication, Types of clinical studies, Experimental design, Cross-over designs, Factorial designs
  • Unit 3: Regression techniques (7 weeks)
    • Lecture topics: Linear regression with dichotomous/categorical predictors, Regression diagnostics, Multiple linear regression, Partial F tests, Interpretation of interaction terms, Stepwise selection/ Alternative model selection approaches, Logistic regression, Model diagnostics for logistic regression
  • Unit 4: Correlated outcomes (7 weeks)
    • Lecture topics: Introduction to longitudinal data, Analysis of response profiles, Fitting curves to longitudinal data, Mixed effects models, Multilevel models, Handling missing data, Types of missing data, Generalized estimating equations
  • Unit 5: Time to event outcomes and advanced techniques (7 weeks)
    • Lecture topics: Kaplan-Meier curves, Log-rank test, Cox proportional hazards regression, Power analysis/study design with survival outcomes, Multiple comparisons, Meta-analysis, Factor analysis

Each week, participants will view a video lecture and will be responsible for completing a quiz and practicum related to the topic for the week. The practicum will demonstrate how to apply the technique in a standard statistical package (STATA®) and provide practice problems so that the concept is reinforced.

Course Completion

Those who view the online videos of all lectures and complete at least 80 percent of the assigned lecture quizzes and practicums will receive a certificate of participation.

The Harvard Catalyst Education Program is accredited by the Massachusetts Medical Society to provide continuing medical education for physicians.

Physicians should claim only the credit commensurate with the extent of their participation in the activity.