Helping researchers navigate clinical & translational research regulatory processes. Regulatory Foundations, Ethics, and Law Program

IRB Reliance

SMART IRB

SMART IRB is a national platform designed to ease common challenges associated with initiating multisite research and to provide a roadmap for institutions to implement the NIH Single IRB Review policy. The SMART IRB Agreement supports IRB reliance among a growing number of SMART IRB Participating Institutions across the nation, including all CTSA hubs as well as numerous CTSA affiliates, and a variety of other institutions and organizations.

SMART IRB is supported by a variety of resources, including the SMART IRB Online Reliance System, which provides a central, web-based mechanism for participating institutions and their investigators to request, track, and document reliance arrangements under the SMART IRB Agreement. Learn more about how to use the Online Reliance System to submit a request for your study. We also recommend you contact your institution's designated SMART IRB Point of Contact to discuss using SMART IRB for your study.

SMART IRB is led by Harvard Catalyst, University of Wisconsin-Madison ICTR, and Dartmouth Synergy.

Learn more or email SMART IRB with any questions.

Harvard Catalyst's Master Reciprocal Common IRB Reliance Agreement (MRA)

Please note: Most institutions that are signatory to the MRA have joined and started using SMART IRB to enable IRB reliance. The Harvard Catalyst IRB Cede Review Request System has been decommissioned; this means there is no longer an online system for requesting and tracking reliance arrangements under the Master Reciprocal Common IRB Reliance Agreement (MRA). Contact your institution's designated representative to discuss the best mechanism to enable IRB reliance for your study.

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