Forsyth Seminar Series: Immunoregulation by Adenosine and Hypoxia – September 13, 2012

The Forsyth Institute presents a seminar by:
Akio Ohta, PhD
Principal Research Scientist
New England Inflammation and
Tissue Protection Institute
Northeastern University
Boston, MA

The immune system has various mechanisms to discourage potentially tissue-damaging immune activation, e.g., anti-inflammatory cytokines and anti-inflammatory cells including regulatory T cells and myeloid-derived suppressor cells. Extracellular adenosine also plays a non-redundant role in the control of immune responses. The increase of adenosine levels in pathophysiological conditions may represent negative feedback mechanism triggered by hypoxia in damaged tissue. Such counterbalance can prevent over-activation of immune responses and consequent excessive tissue injury, but are also able to diminish immune responses to fight against infectious pathogens and cancer cells. Immunoregulatory mechanism through the hypoxia-adenosine pathway may be crucial in the control of pro- and anti-inflammatory balance.

When:                September 13, 2012 at 12:00pm

Where:              The Forsyth Institute
                            17th Floor, Seminar Room A
                            245 First Street
                            Cambridge, MA  02142

For more information, please email Pam Quattrocchi, or call 617-892-8604.