Events in December 2011

  • December 1, 2011

    arrow-rightForsyth Seminar: Periodontitis: a Community Affair

    Time: 12:00 PM - 1:00 PM

    Location: Seminar Room A, 245 First St, 17th Floor, Cambridge, MA 02142

    Speaker:   Richard P. Darveau, Ph.D.

         Chair Dept. of Periodontics

         School of Dentistry

         University Of Washington


    Summary:  The complexity of the sub-gingival microbiota has hindered the identification of the precise microbial etiology of periodontitis although very strong correlations between the amount and composition of the dental plaque biofilm and disease have been described. Furthermore, extensive microbial compositional analysis, based originally on culture techniques and subsequently extended by large scale DNA:DNA hybridization methodologies, has identified potential periopathogens, designated the red complex. Examination of potential virulence characteristics shared by red-complex bacteria, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola, has not yielded clear associations with disease. However, one shared attribute is their ability to either inhibit or evade innate host responses. This talk will provide evidence and a mechanism by which P. gingivalis employs both the microbial community and the host to cause periodontitis in mice.


    Contact: Pam Quattrocchi at 617-892-8604 or via email.

  • December 1, 2011

    arrow-rightDrug Resistance & the Advent of Intelligent Drug Design

    Time: 6:00 PM - 9:00 PM

    Location: TMEC Walter Amphitheater, 260 Longwood Ave, Boston, MA 02115

    Science Shaping Our World (SHOW) is focused on highlighting the current challenges faced with the growing resistance of pathogens to existing therapeutic drugs. Further, we will highlight the advent of intelligent drug design and development towards obviating drug resistance issues in the future. Our outstanding speaker panel draws from the forefront of research and development spanning both academia and industry.


    Please join us for an amazing evening of science, technology, and networking. Event sign-in begins at 5:30 PM at TMEC Walter Amphitheater. Presentation and discussion will follow from 6:00 – 8:00 PM. Further, you are encouraged to bring your business cards, and enthusiasm, for networking following the presentation from 8:00-9:00 PM with networking ice-breaker led by Sarah Cardozo-Duncan founder and CEO at Career Strategist. Light food and refreshments will be provided during the networking portion of the evening.  

    Register at:

  • December 7, 2011

    arrow-rightNew Business from New Science

    Time: 3:30 PM - 5:30 PM

    Location: Batten Hall Lobby, 125 Western Ave, Boston, MA,02163

    Please join Professors Vicki Sato and Woody Yang with the students of Commercializing Science for an event featuring commercialization plans for new science emerging from the broad Harvard community.

    For further details, please contact Robin Smith (email) or Kristen Merrill (email).

  • December 8, 2011

    arrow-rightInformational Webinar: 3rd Generation Real-Time PCR

    Time: 11:00 AM - 1:00 PM

    Location: Bray Room, HMS, 260 Longwood Ave, Boston, MA 02115

    Comparison of three methods for assaying multi-allelic copy number variation at the human 17q21.31 locus


    Speaker: Linda Boettger, Ph.D. Student, Laboratory of Steven McCarroll

    Departmentof Genetics, Harvard Medical School


    17q21.31 is a structurally complex region in the human genome that contains several multi-allelic copy number variants. Using a panel of 180 individuals, we compared three different approaches for quantifying copy number in this region: quantitative PCR, normalized whole genome sequence read depth, and a new droplet-based digital PCR platform. While quantitative PCR decreases in accuracy for copy numbers higher than three, we found that whole genome sequence read depth and droplet-based digital PCR were 99.1% concordant for the copy number genotypes present at this locus (two-six).


    Hosted by the Harvard Catalyst Laboratory for Innovative Translational Technologies (HC-LITT) and the Harvard Catalyst Central Laboratory (HCCL). Harvard University, HC-LITT, HCCL, and Harvard Catalyst do not endorse any company or product. The opinions expressed during this event are solely those of Bio-Rad Laboratories or the speakers and do not represent the views of Harvard Catalyst, HCLITT, HCCL, Harvard University and its affiliated academic health care centers, the National Center for Research Resources, or the National Institutes of Health.

  • December 12, 2011

    arrow-rightApplying Optical Coherence Tomography (OCT) in Biomedical Research

    Time: 4:00 PM - 6:00 PM

    Location: Minot Room, Countway Library, 10 Shattuck St, Boston, MA, 02115

    The Harvard Catalyst Research Navigators and the Center for Optical Coherence Tomography (OCT) Translational Research at Massachusetts General Hospital cordially invite you to a workshop on applying OCT in biomedical research on December 12, 2011.

    OCT has evolved into a powerful microscopy technique for a broad range of biomedical applications. Unlike conventional microscopy and histology, OCT provides three-dimensional perspectives over large fields-of-view. Compositional and functional contrast can be added by integrating birefringence and flow detection. A range of scanning methods, including microscopes, as well as small diameter, flexible catheters and endoscopes, can extend the reach of OCT from whole-tissue and small animal imaging to intravascular and internal organ clinical studies.

    At this workshop, leading experts in OCT will introduce you to recent advances in their field and provide examples of OCT applications in biomedical research. More importantly, you will be encouraged to discuss new ideas for leveraging OCT in your own research and will learn about resources that are available through the Center.

    Attendance at this event is limited to 40 individuals, and registration is required; attendees should RSVP by December 2. Please send your name, home department and institution, and a brief description of your research interests to Amy Webber (E-mail, 617-432-7810). We will include this information in a list of attendees that will be circulated at the event.


    The Harvard Catalyst Research Navigators are committed to providing opportunities for collaboration by organizing scientists and clinicians around research resources, areas of investigation, and disease topics. This event is part of a series of seminars and workshops designed to increase connectivity in the Harvard Catalyst community.