Events in December 2010

  • December 1, 2010

    arrow-rightIntroduction to next generation DNA sequencing

    Time: 08:30 AM - 12:00 PM

    Location: Room 3.110, Simches Research Building, Massachusetts General Hospital, 185 Cambridge Street, Boston

    Registration is now open for a half-day nanocourse organized by the Harvard Catalyst Translational Genetics & Bioinformatics Program on next-generation DNA sequencing. This course is intended for clinical research investigators at the fellow and faculty level and will provide introductory lectures on next generation sequencing topics. Distinguished faculty from across the Harvard community will cover overviews of next generation sequencing instruments, applications, research design, and analyses and storage of large data files.

    This course is offered collaboratively by the Clinical Research Program at Massachusetts General Hospital and Harvard Catalyst. CME credits will be available.

    Registration is required in order to attend. Click here for more information.

  • December 2, 2010

    arrow-rightEnsembl genome browser workshop

    Time: 3:30 PM - 5:30 PM

    Location: Lower Level 2, Room 025, Countway Library, 10 Shattuck Street, Boston

    Ensembl provides unified access to genomic information and annotation for more than 50 eukaryotic species. Learn how to find what you need, from splice sites to regulatory regions to SNPs. We'll also explore the BioMart tool to select and export Ensembl data. With hands-on exercises.

    Click here to register.

  • December 7, 2010

    arrow-rightdChip SNP array analysis: Case studies on LOH and copy number analysis using SNP arrays

    Time: 1:00 PM - 5:00 PM

    Location: Room 403, Countway Library, 10 Shattuck Street, Boston

    DNA-Chip Analyzer (dChip) is a Windows software package for probe-level (e.g., Affymetrix platform) and high-level analysis of gene expression microarrays and SNP microarrays (Li and Wong 2001a, Lin et al. 2004). SNP analysis in dChip includes comparing samples, hierarchical clustering, view expression and SNP data along chromosome, LOH and copy number analysis of SNP arrays, and linkage analysis. This workshop will teach the workings of the dChip application and cover topics such as importing arrays, performing normalization, model based expression calculations, gene and SNP filtering, clustering, linkage, LOH, and copy number analysis.

    Click here to register.

  • December 8, 2010

    arrow-rightRunning your first clinical study

    Time: 4:00 PM - 6:00 PM

    Location: Waterhouse Room, Gordon Hall, Harvard Medical School, 25 Shattuck Street, Boston

    The Harvard Catalyst Research Navigators and the Harvard Catalyst Clinical Research Center (HCCRC) cordially invite investigators interested in the design and execution of clinical studies to a workshop on Wednesday, December 8, 2010. The two-hour session will feature an overview of resources available through the HCCRC, as well as speakers from the Harvard community who will offer tips on how to avoid pitfalls commonly encountered while running clinical protocols. We’ll end with small breakout sessions where you can learn more about the particular resources available at the five Harvard Catalyst Clinical Research Center sites (BIDMC, BWH, CHB, MGH, and MIT).

    Refreshments will be provided, and there will be time for you to network.

    Attendance at this event is limited to 35 individuals, and registration is required. Attendees should RSVP by Tuesday, November 23, 2010. Click here for registration information.

  • December 9, 2010

    arrow-rightUsing Participatory Evaluation to Assess and Improve Health Programs

    Time: 10:00 AM - 12:00 PM

    Location: Minot Room, Countway Library of Medicine, Harvard Medical School, 10 Shattuck Street, Boston

    Join the Harvard Catalyst Community-Based Participatory Research (CBPR) Initiative, the Harvard Catalyst Program for Faculty Development and Diversity (PFDD), and others for an interactive session that will address such questions as:

    • What is participatory evaluation?
    • How you can effectively conduct participatory evaluation?
    • What are the benefits and advantages of this approach?
    • What questions are best suited to participatory evaluation?
    • Where can I get help with my participatory evaluation project?

    The session will also give participants the opportunity to provide specific examples from their own work.

    Community partners and Harvard clinicians and faculty are invited to attend. For more information, contact Jocelyn Chu, ScD, MPH (E-mail, 617-499-6694). Click here to register.

    Sponsored by:

  • December 14, 2010

    arrow-rightAn overview of REDCap

    Time: 09:30 AM - 11:00 AM


    Come learn about Research Electronic Data Capture (REDCap) and REDCap Survey, two free, web-based data management tools available to Harvard investigators through the Harvard-affiliated academic health care centers. Using REDCap, investigators can create and design projects using:

    • A web browser-based Online Form Editor; and/or
    • An offline method by constructing and uploading a “data dictionary” template file in Microsoft Excel.

    Christian Botte, a Harvard Catalyst electronic data capture (EDC) support specialist based at Beth Israel Deaconess Medical Center, will present a series of information sessions at Children’s Hospital Boston in November, December, and January on how to utilize the tools to build and manage online databases and surveys.

    REDCap provides automated export procedures for seamless data downloads to Excel and common statistical packages (SPSS, SAS, Stata, R), built-in project calendars, scheduling module, ad hoc reporting tools, and advanced features including branching logic, file uploading, field validations, and calculations.

    Presented by the Clinical Research Program Education Core at Children’s Hospital Boston, in collaboration with Harvard Catalyst.

    Registration is required in order to attend any of these three sessions. For more information, contact Harvard Catalyst EDC support specialist Christian Botte. To register, visit the Children’s Hospital Boston Clinical Research Program website.

  • December 14, 2010

    arrow-rightAnne Young, MD, PhD: “The Career of a Clinician Scientist”

    Time: 12:00 PM - 1:00 PM

    Location: Bray Room, Harvard Institute of Medicine, Harvard Medical School, 4 Blackfan Street, Boston

    Anne Young, MD, PhD

    Julieanne Dorn Professor of Neurology, Harvard Medical School
    Head of the Department of Neurology, Massachusetts General Hospital

    Lunch will be served, and CME credits are available.

    Seating is limited, and registration is required. Click here for more information.

    The Biomedical Research Institute (BRI) Neurosciences Research Center at Brigham and Women’s Hospital initiated a new series titled “Career Building at a Research Hospital” in May 2010. The purpose of this series is to create a platform for junior and mid-career level scientists and physician researchers to come together to interact with a featured senior faculty member as well as to network with each other and form new collaborations.

  • December 14, 2010

    arrow-rightHTqPCR - high-throughput qPCR analysis in R and Bioconductor

    Time: 1:00 PM - 3:00 PM

    Location: Room 403, Countway Library, Harvard Medical School, 10 Shattuck Streetm Boston

    Quantitative real-time polymerase chain reaction (qPCR) is routinely used for RNA expression profiling, validation of microarray hybridization data, and clinical diagnostic assays. HTqPCR, a package for the R statistical computing environment, enables the processing and analysis of qPCR data in high throughput across multiple conditions or replicates, and in spatially-defined formats such ABI TaqMan Low Density Arrays and conventional 96- or 384-well plates. The workshop is designed to help researchers learn how to install R software and the Bioconductor HTqPCR package; load data into the R environment; and carry out quality assessment, normalization, visualization, and parametric or non-parametric testing for statistical significance in Ct values between features (e.g., genes, microRNAs).

    To register for this or any of the other courses being offered currently by the C3 Bioinformatics initiative, visit the C3 education website. Please note that you will need to have your Harvard University PIN or HMS eCommons ID in order to register for these courses.

  • December 21, 2010

    arrow-rightWhole Transcript Expression analysis using Gene and Exon 1.0 ST arrays

    Time: 1:00 PM - 4:00 PM

    Location: Room 403, Countway Library, 10 Shattuck Street, Boston

    Gene 1.0 ST Arrays are the latest product in the family of Affymetrix expression arrays offering whole-transcript coverage. Each gene is represented on the array by probes spread across the full length of the gene, providing a more complete and more accurate picture of gene expression than 3’-based expression array designs. The Exon Arrays allow for "exon-level" analysis and "gene-level" expression analysis on a single array. Multiple probes per exon enable "exon-level" analysis and allow you to distinguish between different isoforms of a gene. With "gene-level" expression analysis, multiple probes on different exons are summarized into an expression value of all transcripts from the same gene. The hands-on workshop will cover the following topics: installation of Affymetrix Power Tools and R/Bioconductor to normalized and summarize expression values, followed by quality control, filtering, and statistical and differential expression analysis using Bioconductor's oneChannelGUI package.

    Click here to register.