- Eligible* faculty and fellows at the five SHRINE participating institutions.
What is it?
- A web-based query tool that allows investigators to determine the aggregate number of patients seen at participating hospitals who meet clinical criteria of interest.
Why use it?
- Identifying or characterizing potential clinical trial cohorts for recruitment
- Generating new research hypotheses
- Planning or conducting research requiring large sample sizes (e.g., population health studies)
- Preparing grant applications
The Shared Health Research Information Network (SHRINE) helps researchers overcome one of the greatest problems in population-based research: Compiling large groups of well-characterized patients. Eligible investigators may use the SHRINE web-based query tool to determine the aggregate total number of patients at participating hospitals who meet a given set of inclusion and exclusion criteria. The criteria are currently demographics, diagnoses, medications, and selected laboratory values. Because counts are aggregate, patient privacy is protected.
The SHRINE network currently covers six million patients and provides more than 10 billion medical facts from the five participating institutions: Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Massachusetts General Hospital. The data are subject to stringent administrative, physical, and technical safeguards to assure privacy and security.
* Who's eligible: SHRINE is available to faculty (appointed at or above the level of instructor) and fellows employed by one of the SHRINE participating institutions. Fellows may only access SHRINE under the mentorship of an eligible faculty member.
Why Use SHRINE?
Who is using SHRINE?
SHRINE is designed for eligible investigators who want to leverage the vast clinical network of the five participating institutions to answer questions in seconds that might have otherwise taken years. See how it's helped these investigators.
SHRINE is available as an open source platform for institutions seeking a web-based means of identifying cohorts of patients within your own network.
"I use SHRINE to investigate personalized therapies for patients. Rather than relying on clinical trials data as a source of evidence, the approach is to examine the real-world experience of patients similar to ours. This is a shift toward using large-scale observational data sets to form the evidence base."Kenneth Mandl, MD, MPH, Associate Professor of Pediatrics, Boston Children's Hospital
SHRINE National Pilot
SHRINE National Pilot is an implementation of SHRINE technology to create a demonstration network that will include selected, geographically diverse academic health centers from across the United States.
"Continuing in the tradition of the Research Patient Data Registry at Partners HealthCare, SHRINE promotes the broad use of electronic medical records for clinical research in a manner that respects patient confidentiality and can be used in a straightforward way by clinical investigators."Shawn Murphy, MD, PhD, Associate Professor of Neurology, Massachusetts General Hospital, Medical Director, Research Computing, Partners HealthCare