A two-year mentored research & education program for junior faculty and senior fellows. KL2/Catalyst Medical Research Investigator Training

Award Recipients

2016

Amanda Waters Baker, PhD (MGH)
Project: Examining Mechanisms of Treatment Change Using an Intra-Individual Network of Panic Attacks
Mentors: Naomi Simon, MD; Richard McNally, PhD

Steven Corsello, MD (DFCI)
Project: Systematic drug repurposing for cancer therapy
Mentors: Todd Golub, MD; Charles Fuchs, MD

Amit Khera, MD (MGH)
Project: Metabolic and Vascular Characterization of ANGPTL4 Deficiency in Humans
Mentors: Sekar Kathiresan, MD

Margaret Lippincott, MD (MGH)
Project: Kisspeptin Stimulation of Insulin in Women
Mentors: Stephanie Seminara, MD

Peter Moschovis, MD, PhD (MGH)
Project: Developmental origins of chronic respiratory disease in resource-limited settings
Mentors: David Christiani, MD; Patricia Hibberd, MD, PhD

Kent Mouw, MD, PhD (DFCI)
Project: Investigating Genomic Determinants of Chemoradiotherapy Response in Bladder Cancer
Mentors: Alan D'Andrea, MD; Jason Efstathiou, MD, PhD

John O'Malley, MD, PhD (BWH)
Project: Identifying cutaneous T cell lymphoma patients at risk for progression
Mentors: Rachael Clark, MD, PhD

Anne Piantadosi, MD, PhD (MGH)
Project: Virus identification and molecular epidemiology in infectious encephalitis
Mentors: Pardis Sabeti, MD, D.Phil.

Amanda Redig, MD, PhD (DFCI)
Project: Genomic complexity and resistance mechanisms in non-small cell lung cancer
Mentors: Pasi Janne, MD, PhD

Eugene Richardson, MD, PhD (BWH)
Project: Social Epidemiology of Ebola
Mentors: Megan Murray, DPH, MD; Paul Farmer, MD, PhD

Rachel Ross, MD, PhD (BIDMC)
Project: Investigating a cortical - hypothalamic circuit involved in eating disorders
Mentors: Bradford Lowell, MD, PhD; David Jimerson, MD

Eric Sheu, MD, D.Phil. (BWH)
Project: The role of gastrointestinal innate lymphoid cells in diabetes
Mentors: Ali Tavakkoli, MB, BS

Adam Stern, MD (BIDMC)
Project: Predicting Depression Treatment Efficacy from Neuromodulatory Response
Mentors: Alvaro Pascual-Leone, MD, PhD

Elizabeth Stover, MD, PhD (DFCI)
Project: Targeting anti-apoptotic proteins to overcome chemotherapy resistance in ovarian cancer
Mentors: Levi Garraway, MD, PhD; Ursula Matulonis, MD

Ramnath Subbaraman, MD (BWH)
Project: Evaluating 99DOTS, a novel cell phone-based strategy for real-time monitoring of adherence to tuberculosis therapy in people living with HIV/AIDS in India
Mentors: Kenneth Mayer, MD; Beena Thomas, PhD

Jason Wasfy, MD (MGH)
Project: Racial Disparities in Readmission After Acute Myocardial Infarction
Mentors: Francesca Dominici, PhD; Robert Yeh, MD

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2015

Andrew Aguirre, MD, PhD (DFCI)
Project: Functional Characterization of Novel Vulnerabilities in KRAS-mutant Pancreatic Cancer
Mentors: William Hahn, MD, PhD; Charles Fuchs, MD

Kimberly Blumenthal, MD (MGH)
Project: The impact of penicillin allergy on antibiotic use, healthcare-associated infections, resource utilization, and cost
Mentors: Rochelle Walensky, MD; Aleena Banerji, MD

Genevieve Boland, MD, PhD (MGH)
Project: Comparative analysis of circulating exosomal RNA profiles in melanoma responders/non-responders to immunotherapy.
Mentors: David Fisher, MD, PhD; Keith Flaherty, MD

Laura Dichtel, MD (MGH)
Project: Growth Hormone and Intrahepatic Lipid Content in Patients with Nonalcoholic Fatty Liver Disease
Mentors: Karen Miller, MD; Miriam Bredella, MD

Marios Giannakis, MD, PhD (DFCI)
Project: Pathogenesis and therapeutic potential of RNF43 mutations in cancer
Mentors: Levi Garraway, MD, PhD; Charles Fuchs, MD

Rajat Gupta, MD (BWH)
Project: From association to function at the PHACTR1 GWAS locus for coronary atherosclerosis
Mentors: Sekar Kathiresan, MD; Kiran Musunuru, MD, PhD

Grace Huang, MD (BWH)
Project: Prenatal Androgens and Cardiometabolic Risk in Adulthood
Mentors: Shalender Bhasin, M.B.,B.S.; Jill Goldstein, PhD

Dawn Ionescu, MD (MGH)
Project: The Impact of Ketamine on the Reward Circuitry of Suicidal Patients: An MRI Study
Mentors: Jonathan Alpert, MD,PhD; Thilo Deckersbach, PhD

Michael Lobritz, MD, PhD (MGH)
Project: Metabolic aspects of antibiotic efficacy
Mentor: James Collins, PhD

Sagar Nigwekar, MD (MGH)
Project: Role of Vitamin K in Calcific Uremic Arteriolopathy
Mentors: Ravi Thadhani, MD; Sarah L. Booth, PhD

Matthew Stachler, MD, PhD (BWH)
Project: Early TP53 mutations and genomic doubling as a novel path for progression of Barrett's esophagus into esophageal adenocarcinoma
Mentors: Massimo Loda, MD; Adam Bass, MD

Jonathan Swartz, MD (BCH)
Project: Utilizing Whole Exome Sequencing and Genomics to improve our understanding of Disorders of Sex Development and Hypospadias
Mentor: Joel Hirschhorn, MD, PhD

Frederick Wilson, MD, PhD (DFCI)
Project: A Methyltransferase as a Potential Therapeutic Target in Cancer
Mentor: Levi Garraway, MD, PhD

Brian Zanoni, MD, MPH (MGH)
Project: Retention in Care for HIV-infected Adolescents Transitioning to Adult Care
Mentors: Jessica Haberer, MD; David Bangsberg, MD

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2014

Ying Bao , MD, ScD (BWH)
Project: Comprehensive Evaluation of Altered Systemic Metabolism and Pancreatic Cancer Risk
Mentors: Peter Kraft, PhD; Charles Fuchs, MD; Brian Wolpin, MD

Brian Chan, MD (BWH)
Project: Impact of depression and syndemic conditions on people living with HIV in southern India
Mentors: Kenneth Mayer, MD; Alexander Tsai, MD, PhD

Anna Farago, MD, PhD (MGH)
Project: Developing small cell lung cancer xenograft models from circulating tumor cells
Mentors: Jeffrey Engelman, MD, PhD; Alice Shaw, MD, PhD

Medhi Hedjazi Moghari, PhD (BCH)
Project: Creation of 3D Virtual and Physical Heart Models to Guide Cardiac Surgery for Children with Double Outlet Right Ventricle
Mentor: Andrew Powell, MD

Caron Jacobson, MD (DFCI)
Project: HSP-90 inhibition in mantle cell lymphoma
Mentors: David Weinstock, MD; Arnold Freedman, MD

Sahir Kalim, MD (MGH)
Project: The pathophysiology of protein carbamylation in end stage kidney disease
Mentors: Ravi Thadhani, MD; S. Ananth Karumanchi, MB BS

Joseph Mancias, MD, PhD (BIDMC)
Project: Evaluation of glutaminase inhibition as a therapy for pancreatic cancer
Mentors: J. Wade Harper, PhD; Alec Kimmelman, MD, PhD

Elizabeth Mostofsky, ScD (BIDMC)
Project: Absolute Risks in Case-Only Studies using Electronic Health Databases
Mentors: Murray Mittleman, MD, DrPH; Sonia Hernández-Diaz, MD, DrPH

Mandar Muzumdar, MD (DFCI)
Project: CRISPR-based genome editing to identify vulnerabilities in KRAS-dependent pancreatic cancer cells
Mentors: Tyler Jacks, PhD; Charles Fuchs, MD

Jennifer Reedy, MD, PhD (MGH)
Project: Innate Immune Recognition and Response to Fungal Pathogens
Mentor: Jatin Vyas, MD, PhD

Esperance Schaefer, MD (MGH)
Project: Hypoxia and microRNAs in the pathogenesis and diagnosis of NAFLD
Mentor: Raymond Chung, MD

Suman Srinivasa, MD (MGH)
Project: Effect of Mineralocorticoid Blockade on Hepatic Fat and Insulin Resistance in HIV
Mentors: Steven Grinspoon, MD; Gail Adler, MD, PhD

Viviany Taqueti, MD (BWH)
Project: Coronary Flow Reserve to Phenotype Cardiovascular Risk
Mentors: Marcelo Di Carli, MD; Mark Creager, MD

Meghan Underhill, PhD (DFCI)
Project: Pyschosocial experience of living with pancreatic cancer risk
Mentors: Donna Berry, PhD; Sapna Syngal, MD

Jason Vassy, MD (VA Boston)
Project: Informatics Approach to Pharmacogenetics of Statin Safety and Efficacy
Mentors: Robert Green, MD; David Bates, MD

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2013

Justin Baker, MD, PhD (McLean)
Project: Functional Biomarkers of Psychotic State, Trait, and Compensation in Schizophrenia and Related Disorders
Mentors: Dost Ongur, MD, PhD; Randy Buckner, PhD

Roby Bhattacharyya, MD, PhD (MGH)
Project: Transcriptional Signatures of Antibiotic Response in Bacterial Pathogens
Mentor: Deborah Hung, MD, PhD

Jennifer Flythe, MD, MPH (BWH)
Project: The Impact of Hemodialysis Prescription Changes on Cardiovascular Outcomes
Mentors: Gary Curhan, ScD, MD; Steven Brunelli, MD

Joshua Gagne, PharmD, ScD (BWH)
Project: Automated Detection of Drug Interactions in Post-marketing Electronic Databases
Mentors: Sebastian Schneeweiss, SD, MD; Kenneth Mandl, MD

Clemens Hong, MD, MPH (MGH)
Project: Targeting High Risk in Medicaid: A Mixed Methods Approach to Identifying Patients and Opportunities for Intervention to Improve Care and Reduce Costs
Mentors: Lisa Iezzoni, MD; Timothy Ferris, MD

Dae Hyun Kim, MD, MPH (BIDMC)
Project: Functional Status and Disability Following Transcatheter Aortic Valve Replacement
Mentors: Lewis Lipsitz, MD; Francine Grodstein, ScD

R. Coleman Lindsley, MD, PhD (DFCI)
Project: Targeting Mechanisms of Genomic Instability in High-risk Myeloid Malignancies
Mentors: Benjamin Ebert, MD, DPhil; David Steensma, MD

Amit Majithia, MD (MGH)
Project: Making Sense of Sequence: High Throughput Functional Analysis of Protein-altering Variants discovered by large-scale human genome sequencing
Mentors: David Altshuler, MD, PhD; Evan Rosen, MD, PhD

Eric Osborn, MD, PhD (BIDMC)
Project: In Vivo Molecular Imaging of Atherosclerosis and Coronary Stent Healing
Mentors: Farouc Jaffer, MD, PhD; Anthony Rosenzweig, MD

Jessica Savage, MD, MHS (BWH)
Project: Antimicrobial Chemicals in Allergy: Clinical and Mechanistic Associations
Mentor: Augusto Litonjua, MD

Scott Vafai, MD (MGH)
Project: A Chemical-genetic Map for Mitochondrial Disorders
Mentors: Vamsi Mootha, MD; Stanley Shaw, MD, PhD

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2012

Tracy Jennifer Doyle, MD (BWH)
Project: Improved Detection of Rheumatoid Arthritis-associated Interstitial Lung Disease
Mentor(s): Augustine M.K. Choi, MD; Ivan O. Rosas, MD

Ali Gholipour-Baboli, PhD (BCH)
Project: Imaging Biomarkers for Prenatal Screening and Analysis of Congenital Anomalies
Mentor(s): Simon Keith Warfield, PhD; Judy Ann Estroff, MD

Mark Halko, PhD (BIDMC)
Project: Neuroengineering Human Brain Networks in Schzophrenia
Mentor(s): Matcheri S Keshavan, MD; Susan Whitfield-Gabrieli, PhD

Steve Sang-Woo Han, MD, PhD (MGH)
Project: Exploring Mechanisms of Neurodegeneration in ALS Motor Neurons
Mentor(s): Kevin Carl Eggan, PhD

Daniel Kramer, MD (BIDMC)
Project: Implantable Cardioverter-Defibrillator Therapy in Older Patient
Mentor(s): Susan Lisa Mitchell, MD; Matthew R Reynolds, MD

Julie H Levison, MD (MGH)
Project: Defining Barriers to HIV Care for HIV-infected Hispanic Immigrants
Mentor(s): Kenneth Alan Freedberg, MD; Laura M. Bogart, PhD

Mouhsin Shafi, MD, PhD (BIDMC)
Project: TMS-EEG to Assess Cortical Excitability in Epilepsy
Mentor(s): Alvaro Pascual-Leone, PhD, MD; Bernard Shaw-Farn Chang, MD

Erica Seiguer Shenoy, PhD, MD (MGH)
Project: The Impact of Methicillin-Resistant S. aureus (MRSA) Colonization Status on Patient Care and Resource Utilization
Mentor(s): David Crittenden Hooper, MD; Rochelle P. Walensky, MD

Sara Louise Toomey, MD (BCH)
Project: Racial/ethnic Differences in Parent Perspectives of Pediatric Inpatient Care
Mentor(s): Mark A. Schuster, PhD, MD

Patrizia Vannini, PhD (BWH)
Project: Self-awareness, Brain Function and Amyloid in Aging and Alzheimer's Disease
Mentor(s): Reisa Anne Sperling, MD; Keith Alan Johnson, MD

Erin Wamsley, PhD (BIDMC)
Project: Abnormal EEG Patterns in Schizophrenia
Mentor(s): Robert Stickgold, PhD; Dara Sue Manoach, PhD

Markella V. Zanni, MD (MGH)
Project: Atherosclerotic Plaque Inflammation in ART-Naive HIV+ Subjects at Baseline and in Response to Newly Initiated ART
Mentor(s): Steven Kyle Grinspoon, MD; Joseph Loscalzo, MD, PhD

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2011

Ovidiu Andronesi, PhD (MGH)
Project: Imaging Biomarkers and Treatment Response in Gliomas with IDH Mutations
Mentor(s): Bruce Rosen, PhD, MD; Matthew Vander Heiden, MD, PhD

Matt Bianchi, MD, PhD (MGH)
Project: Quantitative Phenotyping of Insomnia: Improving Management Through Longitudinal Home Sleep Monitoring
Mentor(s): Andrew Nierenberg, MD; Elizabeth Klerman, PhD, MD

Benjamin Brent, MD (BIDMC)
Project: Brain Activity During 'Social Reflection' and the Genetic Risk for Schizophrenia: An fMRI Study
Mentor(s): Larry Seidman, PhD; Daphne Holt, MD, PhD

Nancy Cho, MD (BWH)
Project: Predictors of Adenoma Recurrence in a Colorectal Adenoma Prevention Trial
Mentor(s): Monica Bertagnolli, MD; Francis Moore, MD

Mirna Lechpammer, PhD, MD (BCH)
Project: FMRP/mTOR Cascade in the Hypoxic/Ischemic Brain Injury and its Cognitive Sequelae
Mentor(s): Frances Jensen, MD; Rebecca Folkerth, MD

Brad Manor, PhD (BIDMC)
Project: Balance, Sensory Loss, and Neural Adaptation in Aging
Mentor(s): Lewis Lipsitz, MD; Vera Novak, PhD, MD

Nina Paynter, PhD (BWH)
Project: Genetic Effects on Statin-induced Changes in HbA1c: Pathways and Prediction
Mentor(s): Paul Ridker, MD; Daniel Chasman, PhD

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2010

Nadia Ahmad, MD (MGH)
Project: Bile Acids in Surgically-induced Weight Loss
Mentor(s): Lee Kaplan, MD, PhD

Bindu Chamarthi, MD (BWH)
Project: Evaluation of Urinary Free Cortisol as a Genetically Determined Intermediate Phenotype of Essential Hypertension
Mentor(s): Jose Romero, PhD; Gordon Williams, MD

Pouneh Fazeli, MD (MGH)
Project: The Effects of Acute Calorie Deprivation on Adipose Tissue Distribution and Bone Mass
Mentor(s): Anne Klibanski, MD

Jason Gaglia, MD (HMS)
Project: Monitoring Autoimmunity in Type 1 Diabetes
Mentor(s): Diane Mathis, PhD

Shamsah Kazani, MB, BS (BWH)
Project: Pharmacogenomics and Biomarkers of the Leukotriene Pathway Polymorphisms in Asthma
Mentor(s): Elliot Israel, MD

Michael Ross, MD, PhD (BIDMC/BWH)
Project: Identification of Genetic Causes of Familial Focal Segmental Glomerular Sclerosis Using Whole Exome Capture and High-throughput Sequencing
Mentor(s): Martin Pollak, MD

Mert Sabuncu, PhD (MGH)
Project: Integrating Neuroimaging and Genetics for Characterizing Alzheimer's Risk
Mentor(s): Bruce Fischl, PhD

Kendra Taylor, PhD (MGH)
Project: Regulation of B-cell Tolerance in Autoimmune Diseases
Mentor(s): Shiv Pillai, PhD, MD

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2009

Edwin Choy, MD, PhD (MGH)
Project: Phase I/II Study of HDAC Inhibition to Reverse Doxorubicin Resistance in Sarcomas
Mentor(s): Bruce Chabner, MD

Florencia Halperin, MD (BWH)
Project: Mechanisms of Improvement of Type 2 Diabetes after Roux-en-Y Gastric Bypass
Mentor(s): Allison Goldfine, MD

Timothy Henrich, MD (BWH)
Project: Exploring HIV-1 Coreceptor Usage and Host Genetic Factors
Mentor(s): Daniel Kuritzkes, MD

Kun Hu, PhD (BWH)
Project: Fractal Regulatory Function of the Circadian System
Mentor(s): Steven Shea, PhD; Clifford Saper, MD, PhD

Damon Hyde, PhD (BCH)
Project: Noninvasive Source Localization in Pediatric Epilepsy
Mentor(s): Simon Warfield, PhD

Ingrid Katz, MD, MSc (BWH)
Project: Adherence to the HPV Vaccine in a Resource Limited Setting
Mentor(s): David Bangsberg, MD

Lindsay Oberman, PhD (BIDMC/BCH)
Project: Plasticity Mechanisms in Children with Autism Spectrum Disorders
Mentor(s): Alvaro Pascual-Leone, MD, PhD; Alexander Rotenberg, MD, PhD

Ali Tavakkolizadeh, MD (BWH)
Project: Role of Taste Receptors in Resolution of Diabetes after Gastric Bypass Surgery
Mentor(s): Joseph Avruch, MD

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2008

Sherry Hsiang-Yi Chou, MD (BWH/MGH)
Project: Biomarkers of Delayed Ischemic Damage following Subarachnoid Hemorrhage
Mentor(s): Steven Feske, MD; MingMing Ning, MD

Aaron Cypess, MD, PhD (Joslin)
Project: Biology of Brown Adipose Tissue in Adult Humans
Mentor(s): C. Ronald Kahn, MD

Yvonne Lee, MD (BWH)
Project: Association and Mechanisms of Pain Extent and Functional Outcomes in Rheumatoid Arthritis Patients
Mentor(s): Elizabeth Karlson, MD

Melanie Pogach, MD (BIDMC)
Project: Assessment of the Effects of Partial Sleep Deprivation on Insulin Responsiveness
Mentor(s): J. Woodrow Weiss, MD

Luminita Pojoga, PhD (BWH)
Project: Association of Caveolin-1 Polymorphisms, Insulin Resistance, and Hypertension
Mentor(s): Gail Adler, MD, PhD; Scott Weiss, MD

Joseph Schwab, MD (MGH)
Project: Immunotherapy of Human Chordomas
Mentor(s): Francis Hornicek, MD, PhD

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Learn how KL2/Catalyst Medical Research Investigator Training support is helping one investigator shed light on the mechanisms of autism.

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Have you received a KL2/Catalyst Medical Research Investigator Training award? Remember to cite Harvard Catalyst in your publications and posters.