Request single or consolidated IRB review for a multi-site study. IRB Cede Review Request
At a glance
Key Features
  • Request that one IRB review proposed multi-site clinical protocols on behalf of all involved IRBs
  • Request single IRB review when adding new site(s) to existing protocols
Useful for
  • Reducing the complexity of the IRB review process for multi-site clinical research.
Available to
  • Clinical investigators and study staff *
Login via HMS eCommons ID or Harvard PIN required. Need Help?

The Harvard Catalyst Regulatory Foundations, Ethics, and Law Program and institutional review boards (IRBs) covering 24 Harvard Catalyst-participating institutions developed the IRB Cede Review Request form to support the Master Reciprocal IRB Reliance Agreement and help facilitate multi-site human studies. The form may be used for any multi-site studies which involve at least one Harvard Catalyst-participating institution.

Harvard Catalyst-affiliated investigators may request ceded IRB review for multicenter studies via the IRB Cede Review Request form before submitting a full IRB application. The IRBs will review the request and work together to determine whether the proposed research warrants individual regulatory reviews by each institution's IRB, or if review by a single IRB will be sufficient.

MIT-affiliated investigators should contact Catherine Ricciardi to request an eCommons ID.

Other non-Harvard-affiliated investigators should contact their IRB administrators for guidance on requesting IRB reliance. Investigators not affiliated with a Harvard Catalyst-participating institution may work with a Harvard Catalyst-collaborating investigator to request reliance via the IRB Cede Review Request form or, if not collaborating with a Harvard Catalyst investigator, communicate with their institution's IRB Cede Review Request contact for specific instructions on how to request IRB reliance under the Reciprocal Common Reliance Agreement.

In order to request ceded review, investigators should complete and submit a cede review request prior to submitting their IRB application.

When to use this form

  • Investigators should use this form before submission of an IRB application but after their research plans have been finalized.
  • For research that has previously been reviewed and approved, this form may also be used to request review by a single IRB by adding a new site to an existing protocol.

Note that if your computer remains idle for more than 59 minutes while you are completing the Cede Review Form, your data will be lost. You will have the option to save your work at any time and continue later.

We suggest compiling the following required information before filling out the form:

  • Your HMS eCommons ID and password or Harvard PIN. Investigators can only access the Cede Review Form using their eCommons or Harvard PIN credentials. Need help?
  • The name of the institution where the overall principal investigator (Overall PI) is "primarily employed." Although investigators may have appointments at multiple institutions, they are usually considered an "employee" or a "workforce member" of only one institution. The institution from which the Overall PI receives his/her paycheck is generally considered the institution of primary employment. For Harvard University employees, this would be the school at which their primary appointment is held.
  • Which IRB is being requested to review and the reason(s) why.
  • Title and brief description of your research.
  • The sites where the research will be conducted.
  • The activities which will be conducted at each site.
  • The contact information for the site investigators.
  • The names of the other research personnel at each site who will work on the proposed study.
  • If this research has already been approved by an IRB, the protocol's IRB approval number.
  • Your funding information.

* While the IRB Cede Review Request System supports collaboration, access is limited to Harvard Catalyst-affiliated investigators and staff, and requires HMS eCommons ID or HUID login.

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