Genetics Nanocourses

Nanocourses are half- to one-day events that give an overview of a particular topic in genomics and genetics. Nanocourses are open to all members of institutions affiliated with Harvard Catalyst.

Upcoming Nanocourses

Proteomics

Tuesday, June 12
12:30 PM to 4:30 PM
Massachusetts General Hospital
Simches Research Building, Room 3.110
185 Cambridge Street, Boston

This course is offered collaboratively by the MGH Clinical Research Program, Harvard Catalyst, Beth Israel Deaconess Medical Center, the Broad Institute, Children's Hospital Boston, and Dana-Farber Cancer Institute.

This introductory proteomics course is intended for clinicians, investigators, graduate and medical students, nurses, and other clinical research staff with an interest in proteomics, personalized medicine, and disease biomarkers. It will introduce fundamental language and concepts including basic concepts of mass spectrometry, sample preparation, quantitative proteomics, protein-protein interaction networks, post-translational modifications, proteomics data analysis, proteomic biomarker discovery and validation, translational introduction of diagnostic and prognostic biomarkers into the clinic, proteomics approaches to understand basic disease mechanisms and to identify potential novel drug targets, as well as applications for personalized medicine.

Key principles necessary for basic, clinical, and translational researchers to design proteomic studies and to perform and analyze proteomic data will be discussed. Participants will have the opportunity to submit questions to the faculty prior to the lectures.

12:30 – 12:40PM	Towia Libermann, PhD	Introduction
12:40 – 1:25PM	Jarrod Marto, PhD	Qualitative Proteomics
1:25 – 2:10PM	Hanno Steen, PhD	Quantitative Proteomics 101
2:10 – 2:30PM	Break
2:30 – 3:15PM	Towia Libermann, PhD	Proteomics Driving Personalized Medicine
3:15 – 4:00PM	Steve Carr, PhD	Applications of Quantitative Proteomics in Chemistry, Biology and Medicine
4:00 – 4:30PM	Conclusion and Panel Discussion

Registration is required. Please contact Suzanne Powell with any questions.

This course is part of a CME series in Genetics and Genomics which also includes courses in Pharmacogenomics and Sequencing. Upon completion of this CME series, participants will be able to utilize basic concepts of genetics and genomics in the conduct of clinical research.

Course Director: Eric Rosenberg, MD, Co-Director, Education Unit, Clinical Research Program, MGH

Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Harvard Medical School designates this live activity for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Epigenetics: An Introduction and Applications

This course will be offered in early 2012.

This course is intended for clinical research investigators at the fellow and faculty level. Distinguished faculty from MGH will provide introductory lectures defining epigenetics and its effect on gene regulation and inherited disease.

2011 Faculty and Topics included:

Robert Kinston, PhD, Chief, Department of Molecular Biology, MGH: “Introduction to Epigenetic Mechanisms”

Johnathan Whetstein, PhD, MGH Cancer Center; Assistant Professor of Medicine, HMS: "Histone Methylation: Chemically Inert but Chromatin Dynamic"

Bradley Bernstein, MD, PhD, Associate Pathologist, MGH; Associate Professor of Pathology, HMS: “What Can the Epigenome Teach Us About Cellular States and Disease?"

Course Director: Eric Rosenberg, MD, Co-Director, Education Unit, Clinical Research Program, MGH

This course is part of a CME series in Genetics and Genomics which also includes courses in Genetic Literacy and Sequencing. Upon completion of this CME series, participants will be able to: utilize basic concepts of genetics and genomics in the conduct of clinical research.

Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Harvard Medical School designates this live activity for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Sponsored by the MGH Clinical Research Program and Harvard Catalyst.

Past Nanocourses

Next Generation Sequencing at Harvard: Resources and Applications

Monday, March 12, 2012
9:00am-5:00pm
Massachusetts General Hospital
Simches Research Building
Rooms 3.110, 3.120, and 3.130
185 Cambridge Street, Boston

This program is sponsored by the MGH Clinical Research Program, Harvard Catalyst TGBP, and the Harvard Catalyst Research Navigators

This symposium is intended for investigators at all levels interested in next-generation sequencing resources and applications available across Harvard. The course will include an introductory lecture on next-generation sequencing methodologies, lectures on scientific applications, and presentations by seven facilities performing next-gen sequencing. The goal is to provide attendees with fundamental knowledge of this important tool, and the information needed to access sequencing facilities.

The symposium will feature faculty and facility representatives from:

• Broad Institute of MIT and Harvard
• Dana-Farber Cancer Institute
• Harvard Medical School
• Harvard University FAS
• Massachusetts General Hospital

There will be an introductory lecture on methodologies by Niall Lennon, Broad Institute; as well as applications lectures by George Church, Ph.D., HMS; Mike Talkowski, Ph.D., MGH; and Matthew Meyerson, M.D., Ph.D., DFCI.

The complete program will be posted by 2/17/12.

Course Director: Eric Rosenberg, MD, Co-Director, Education Unit, Clinical Research Program, MGH

Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

This course is part of a CME series in Genetics and Genomics which also includes courses in Genetic Literacy and Sequencing. Upon completion of this CME series, participants will be able to utilize basic concepts of genetics and genomics in the conduct of clinical research.

Harvard Medical School designates this live activity for a maximum of 2.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Sponsored by the MGH Clinical Research Program and Harvard Catalyst.

Adding Pharmacogenomics to Clinical Investigation: A Practical Guide

Tuesday, December 13, 2011
12:30pm to 5:00pm
MGH, Simches Room 3.110

In this half-day course, distinguished faculty will discuss the diverse ways pharmacogenetic studies have been conducted, from small translational studies to clinical trials to large-scale cohort studies. They will address key principles necessary for clinical researchers to design, conduct, and analyze such studies.

This program is intended for clinicians, investigators, nurses, and other clinical research staff with an interest in genetics and genomics.

Pharmacogenomics in Clinical Trial Design
Roy Perlis, MD, MSc, Assistant Professor of Psychiatry, HMS, Director, Pharmacogenomics Research, Psychiatry, MGH

This presentation will address strategies for incorporating genetics and other biomarkers in phase 2-4 clinical trials, including biomarker-stratified and biomarker-enriched designs.

Creation and Characterization of Patient-Derived Cellular Models
Stephen Haggarty, PhD, Assistant Professor, HMS

This presentation will describe induced pluripotent stem cell and induced neuronal models and their application in clinical trials and other investigations of pharmacogenomics.

Pharmacogenetics of Clopidogrel
Marc Sabatine, MD, MPH, Associate Physician in Cardiovascular Medicine, BWH, Associate Professor of Medicine, HMS

This presentation will summarize pharmacogenetic investigation of antiplatelet therapies and place such studies in a clinical context.

Overview of Human Subjects Issues in Pharmacogenetic Research
Jordan Smoller, M.D., Sc.D., Associate Professor of Psychiatry, Center for Human Genetic Research, MGH

Course Director: Eric Rosenberg, MD, Co-Director, Education Unit, Clinical Research Program, MGH

This course is part of a CME series in Genetics and Genomics which also includes courses in Genetic Literacy and Sequencing. Upon completion of this CME series, participants will be able to: utilize basic concepts of genetics and genomics in the conduct of clinical research.

The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Harvard Medical School designates this live activity for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.