- Continuing education on recent advances in biostatistics
|Talks focused on translating recent advances in biostatistics into practice.||Biostatistics Seminar Series|
During the 2013-14 academic year, the Harvard Catalyst Biostatistics Program will present a series of talks based on recent advances in biostatistics, but with a focus on translation of those ideas to biostatistical practice. Speakers will provide detailed examples of the application of methods, often including discussion of software, code, and worked examples.
Bernard Rosner, PhD
Professor in the Department of Biostatistics, Harvard School of Public Health
Professor of Medicine (Biostatistics), Harvard Medical School
November 13, 2013
Harvard School of Public Health, FXB G-13
A marker of validity of a dietary instrument is how well it correlates with a relevant biomarker. For example, there are different methods of assessing dietary Beta carotene (e.g., 24-hour recall, food frequency questionnaire, diet record) and a natural question is which measure correlates most strongly with plasma Beta carotene. Indeed, there already exist methods for comparing dependent correlation coefficients (e.g., Wolfe, 1976; Steiger, 1980; Meng, 1992). However, each of these instruments has associated random error and a related question is after correcting for random error, which instrument correlates most highly with plasma Beta carotene. Since these correlations are assessed from the same subjects, the more general question is how can we compare dependent deattenuated correlation coefficients. This is a generalization of previous work for obtaining confidence limits for a single deattenuated correlation coefficient (Rosner and Willett, 1988). In addition, we extend this work to the comparison of dependent Spearman correlation coefficients, which to our knowledge has never been done before. These methods are illustrated with two examples, (a) the comparison of the validity of different methods for measuring dietary Beta carotene and (b) the comparison of the validity of different storage protocols in processing plasma samples for the determination of HgbAlc.
Slides from Dr. Rosner's presentation.
Watch Dr. Rosner's presentation.