Talks focused on translating recent advances in biostatistics into practice. Biostatistics Continuing Education

This series meets monthly and leadership rotates among Harvard Catalyst statisticians. The leader selects an article on a topic of interest to Harvard Catalyst statisticians and leads discussion of the article. The meeting takes place in person, as well as through web and teleconference interfaces. This series also includes "work-in-progress" sessions, in which a statistician will present preliminary research or investigations on a technical topic of interest. The session is intended to be highly participatory with active exchange of ideas.

The journal club discussions are posted on our Harvard Medical School wiki (behind HMS eCommons login). Please email us to request access (must have an eCommons account).

September 2017 Work-in-Progress

Title: Control of False Positives in Randomized Phase III Clinical Trials

Changyu Shen, PhD
Associate Professor of Medicine, Harvard Medical School
Lead Statistician in the Smith Center for Outcomes Research in Cardiology, BIDMC
September 27, 2017
1:00pm-2:00pm
Harvard T.H. Chan School of Public Health, Room 2-426

Please join us for this work-in-progress meeting. The leader of this meeting will be Changyu Shen, Associate Professor of Medicine, Harvard Medical School, and Lead Statistician in the Smith Center for Outcomes Research in Cardiology, BIDMC. Dr. Shen will be presenting research to discuss the control of false positives in randomized phase III clinical trials. The session is intended to be highly participatory with an active exchange of ideas.


Past Biostatistics Journal Clubs/Work in Progress


August 2017 Journal Club

Read more for details.

Edie Weller, PhD
Director of Biostatistics and Research Design Core, Institutional Centers for Clinical and Translational Research, Boston Children's Hospital
August 29, 2017
1:00pm - 2:00pm
Harvard T.H. Chan School of Public Health, Room 2-426

Dr. Edie Weller, Director of Biostatistics and Research Design Core at Boston Children's Hospital, will discuss the following article: "Performance of toxicity probability interval based designs in contrast to the continual reassessment method," BJ Horton et al., Stat Med. 2017 Jan 30;36(2):291-300. doi: 10.1002/sim.7043. Epub 2016 Jul 19. PMID: 27435150.

Journal Club Reading

Slides from Dr. Weller's presentation


July 2017 Journal Club

Read more for details.

Kush Kapur, PhD
Assistant Professor of Neurology
Boston Children's Hospital
July 18, 2017
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Dr. Kush Kapur, Assistant Professor of Neurology at Harvard Medical School and Senior Biostatistician at Boston Children's Hospital, will discuss the following article: Guo W. "Functional data analysis using smoothing splines" Stat Methods Med Res.2004 Feb; 13 (1): 49-62.

Journal Club reading

Slides from Dr. Kapur's presentation


June 2017 Journal Club

Read more for details.

Jacqueline Starr, PhD
Director, Epidemiology and Biostatistics Core, Forsyth Institute
Lecturer, Department of Oral Health Science and Epidemiology, Harvard School of Dental Medicine
June 27, 2017
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. Dr. Jacqueline Starr, Director, Epidemiology and Biostatistics Core at the Forsyth Institute and Lecturer, Department of Oral Health Science and Epidemiology, Harvard School of Dental Medicine, will discuss the following article: Wang, J. J. J., Bartlett, M., and Ryan, L. (2017) "Non-ignorable missingness in logistic regression," Statistics in Medicine, doi: 10.1002/sim.7349.

Journal Club Reading

Slides from Dr. Starr's presentation


May 2017 Work-In-Progress

Read more for details.

Title: Estimation for a Composite Endpoint Analysis

Dianne Finkelstein, PhD
Professor of Biostatistics, Harvard T.H. Chan School of Public Health
Professor of Medicine, Harvard Medical School, MGH
May 23, 2017
12:30pm-1:30pm
MGH Biostatistics Center, 50 Staniford Street, Suite 560

Please join us for this work-in-progress meeting. The leader of this meeting will be Dianne Finkelstein, Professor of Medicine, Harvard Medical School, MGH, and Professor of Biostatistics, Harvard T.H. Chan School of Public Health. Dr. Finkelstein will be presenting research to discuss the estimation for a composite endpoint analysis. The session is intended to be highly participatory with an active exchange of ideas.


April 2017 Journal Club

Read more for details.

Wei Wang, PhD
Assistant Professor of Medicine
Brigham and Women's Hospital

April 19, 2017
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Journal Club Reading 1
Journal Club Reading 2

Slides from Dr. Wang's presentation


February 2017 Journal Club

Read more for details.

Dihua Xu, PhD
Statistician, MGH
February 16, 2017
12:30pm-1:30pm
MGH Biostatistics Center, 50 Staniford Street, Suite 560

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. Dr. Dihua Xu, Statistician at MGH, will discuss the following article: Pearce, Neil "Analysis of matched case-control studies." BMJ 2016; 352: i969.

Journal Club Reading


January 2017 Journal Club

Read more for details.

Elissa Wilker, ScD
Assistant Professor of Medicine
Beth Israel Deaconess Medical Center
January 30, 2017
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. Dr. Elissa Wilker, Assistant Professor of Medicine at BIDMC, will discuss the following article: Benjamin A. Goldstein et. al. "Controlling for Informed Presence Bias Due to the Number of Health Encounters in an Electronic Health Record" American Journal of Epidemiology, November, 2016; Vol. 184 (11): 847-855.

Journal Club Reading


December 2016 Journal Club

Read more for details.

Kush Kapur, PhD
Assistant Professor of Neurology
Boston Children's Hospital
December 7, 2016
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Dr. Kush Kapur, Assistant Professor of Neurology at Harvard Medical School and Senior Biostatistician at Boston's Children's Hospital, will discuss the following article: Fulvio De Santis "Using Historical Data for Bayesian Sample Size Determination" J. R. Statist. Soc. A. (2007) 170, Part 1, pp. 95-113.

Journal Club reading

Slides from Dr. Kapur's presentation


November 2016 Journal Club

Read more for details.

Bernard Rosner, PhD
Professor, Department of Biostatistics, Channing Laboratory
Professor of Medicine, HMS
November 22, 2016
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Dr. Bernard Rosner, Professor of Medicine (Biostatistics) at Harvard Medical School, will discuss the following article: Douglas J. Lorenz et al. "Marginal Association Measures for Clustered Data" Stat Med. 2011 November 30; 30(27): 3181-3191.

Journal Club Reading

Slides from Dr. Rosner's presentation


October 2016 Journal Club

Read more for details.

Hillary Keenan, PhD, Assistant Professor of Medicine, HMS
David Pober, PhD, Biostatistician, Joslin Diabetes Center
October 20, 2016
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, Room 2-426

Dr. Hillary Keenan, Epidemiologist at Joslin Diabetes Center and Assistant Professor of Medicine at Harvard Medical School, and Dr. David Pober, Biostatistician at Joslin Diabetes Center, will discuss the following article: Dana Pascovici et al. "Multiple testing corrections in quantitative proteomics: a useful but blunt tool" Proteomics, in press (2016). The second article, Angel P. Diz et al. "Multiple Hypothesis Testing in Proteomics: A Strategy for Experimental Work" Mol Cell Peoteomics 10(3) (2011), is supportive reading for the topic but will not be presented.

Journal Club Reading (1)

Journal Club Reading (2)


September 2016 Journal Club

Read more for details.

Dianne Finkelstein, PhD
Professor of Biostatistics, HMS
September 22, 2016
12:30pm-1:30pm
MGH Biostatistics Center, 50 Staniford Street, Suite 560

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Dianne Finkelstein, Professor of Biostatistics at Harvard Medical School. The following article will be discussed: Faiez Zannad et al. "When to Stop a Clinical Trial Early for Benefit: Lessons Learned and Future Approaches," Circulation: Heart Failure, 5, 294-302 (2012 ).

Journal Club Reading

Slides from Dr. Finkelstein's presentation


June 2016 Journal Club (2)

Read more for details.

Mark Vangel, PhD
Assistant Professor of Radiology, HMS; Biomedical Imaging Core, MGH
June 22, 2016
1:30pm-2:30pm, MGH, 50 Staniford Street, Suite 560

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Mark Vangel, Assistant Professor of Radiology at Harvard Medical School. The following article will be discussed: Katherine S. Button, John P.A. Ioannidis, Claire Mokrysz, Brian A. Nosek, Jonathan Flint, Emma S.J. Robinson and Marcus R. Munafo. "Power failure: why small sample size undermines the reliability of neuroscience," Nature Reviews: Neuroscience, 14, 365-376 (2013).

Journal Club Reading


June 2016 Journal Club (1)

Read more for details.

Rebecca Betensky, PhD
Professor of Biostatistics
June 1, 2016
12:30pm-1:30pm
Harvard T.H. Chan School of Public Health, FXB G-10

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Rebecca Betensky, PhD, Professor of Biostatistics and Program Director of the Harvard Catalyst Biostatistics Program. The following article will be discussed: Ronald L. Wasserstein & Nicole A. Lazar (2016): The ASA's statement on p-values: context, process, and purpose. The American Statistician.

Journal Club Reading


April 2016 Journal Club

Read more for details.

Jacqueline Starr, PhD, MS, MPH, and Kyu Ha Lee, PhD
April 27, 2016
12:30pm-1:30pm, HSPH, Building 2, Room 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leaders of this meeting will be Dr. Jacqueline Starr, PhD, MS, MPH, Associate Member and Director of the Epidemiology and Biostatistics Course at The Forsyth Institute, and Kyu Ha Lee, PhD, Assistant Research Investigator at The Forsyth Institute.

Journal Club Readings


March 2016 Journal Club

Read more for details.

Roger Davis, ScD
March 22, 2016
12:30pm-1:30pm, HSPH, Building 2, Room 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Roger Davis, ScD, Associate Professor in the Department of Biostatistics at Harvard T.H. Chan School of Public Health.

Slides from Dr. Davis's presentation.


February 2016 Journal Club

Read more for details.

Henry Feldman, PhD
February 17, 2016
12:30pm-1:30pm, HSPH, Building 2, Room 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Henry Feldman, PhD, Associate Professor of Pediatrics at Children's Hospital Boston.


January 2016 Journal Club

Read more for details.

Linda Valeri, PhD
January 13, 2016
11:00am-noon, HSPH, Building 2, Room 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Linda Valeri, PhD, Assistant Biostatistician at McLean Hospital, and Instructor in Psychiatry at Harvard Medical School.


December 2015 Journal Club

Read more for details.

Robert Glynn, ScD
December 2, 2015
12:30pm-1:30pm, HSPH, Building 2, Room 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Robert Glynn, ScD, Professor of Biostatistics at Harvard T.H. Chan School of Public Health, and Professor of Medicine at Harvard Medical School.


October 2015 Journal Club

Read more for details.

Joseph Locascio, PhD
October 28, 2015
12:30pm-1:30pm, MGH, 50 Staniford St., Suite 560, Rm 560F

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Joseph Locascio, PhD, Assistant Professor of Neurology at the Massachusetts General Hospital. Dr. Locascio discussed "The Null Hypothesis Significance Test (NHST) Controversy" concerning the criticisms that statisticians have had over the years about NHST, especially the recent banning of the use of NHST in the journal Basic and Applied Social Psychology (BASP).

Return to top


September 2015 "Work in Progress"

Read more for details.

David Schoenfeld, PhD, Douglas Hayden, PhD, Brian Healy, PhD, Eric Macklin, PhD
September 18, 2015
12:30pm-1:30pm, MGH, 50 Staniford St., Suite 560, Rm 560F

Please join us for our first Work in Progress meeting. These meetings will occur quarterly, and it will give presenters a chance to present ongoing work and seek feedback from the biostatistical community. The leaders of this first meeting will be Drs. David Schoenfeld, PhD, Douglas Hayden, PhD, Brian Healy, PhD, and Eric Macklin, PhD, all from MGH. The discussion revolved around the questions of what power and alpha level should be in different contexts, and how we explain the issues to investigators.

Slides from this meeting.


August 2015 Journal Club

Read more for details.

Hillary Keenan, PhD
August 5, 2015
12:30pm-1:30pm, HSPH, FXB G-10

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Hillary Keenan, PhD, Instructor in Medicine at the Joslin Diabetes Center. Dr. Keenan discussed the article "Prevalence of Detectable C-Peptide According to Age at Diagnosis and Duration of Type 1 Diabetes" Diabetes Care 38:476-481; 2015- with a focus on a discussion of when is imputation "OK."


June 2015 Journal Club

Read more for details.

Caterina Stamoulis, PhD
June 24, 2015
12:30pm-1:30pm, HMS Countway Library, Ware Room

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Caterina Stamoulis, PhD, Assistant Professor of Radiology at Harvard Medical School. Dr. Stamoulis discussed assessing statistical significance in causal graphs.


May 2015 Journal Club

Read more for details.

Murray Mittleman, DrPH, MD, D.Ec.
May 27, 2015
12:30pm-1:30pm, Harvard T. H. Chan School of Public Health, Bldg 2, Rm 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Murray Mittleman, MD, Associate Professor of Medicine at Harvard Medical School, and Associate Professor of Epidemiology at Harvard T.H. Chan School of Public Health. Dr. Mittleman discussed propensity scores through the article, "A tutorial on propensity score estimation for multiple treatments using generalized boosted models."

Return to top


April 2015 Journal Club

Read more for details.

Wei Wang, PhD
April 15, 2015
12:30pm-1:30pm, Harvard T.H. Chan School of Public Health, Bldg 2, Rm 426

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Wei Wang, PhD, Associate Mathematician in the Division of Sleep and Circadian Disorders in the Department of Medicine and Neurology at Brigham and Women's Hospital. Dr. Wang discussed the challenges of big data analysis through Jianqing Fan, Fang Han, Han Liu, Challenges of Big Data analysis. National Science Review 1: 293-314, 2014, doi: 10.1093/nsr/nwt032.


March 2015 Journal Club

Read more for details.

Robert Parker, ScD
March 25, 2015
12:30pm-1:30pm, MGH, 50 Stanford Street, Suite 560, Room 560F

Please join us for this meeting of the Harvard Catalyst Biostatistics Journal Club. The leader of this meeting will be Dr. Robert Parker, ScD, Associate Professor of Medicine at the Massachusetts General Hospital. Dr. Parker discussed disease modeling through Childs, L.M., et al., Modelling challenges in context: Lessons from malaria, HIV, and tuberculosis. Epidemics (2015), and Metcalf, C.J.E., et al., Six challenges in modelling for public health policy. Epidemics (2014).

Return to top


February 2015 Journal Club

Read more for details.

February 5, 2015
12:30-1:30pm, Harvard T.H. Chan School of Public Health, Building 2, 426

Please join us for the first meeting of the Harvard Catalyst Biostatistics journal club on Wednesday, January 28, 2015, 12:30-1:30pm. The leader of this first meeting will be Dr. Jacqueline Starr, MS, MPH, PhD, Director of the Epidemiology and Biostatistics Core at the Forsyth Institute. Dr. Starr discussed Pepe MS, Janes H, Li CI. Net Risk Reclassification P Values: Valid or Misleading? JNCI J Natl Cancer Inst (2014) 106(4).

Return to top