Access the resources of five Harvard Catalyst clinical research centers. Harvard Catalyst Clinical Research Center (HCCRC)


Beth Israel Deaconess Medical Center

The Harvard Catalyst Clinical Research Center (HCCRC) at Beth Israel Deaconess Medical Center (BIDMC) provides a wide array of services and facilities to investigators, including: bed and board; routine and specialized nursing care; routine and specialized nutrition services; research coordination services; assistance with specimen collection, measurement and long term sample storage; and outpatient interview rooms, examination rooms, and specialty testing labs. Research support may be provided within our research unit or by our staff in other locations in the hospital.

The HCCRC at BIDMC is located on the East Campus of the Beth Israel Deaconess Medical Center on the eighth floors of the Gryzmish and Feldberg buildings. The CRC provides space for inpatient, outpatient, laboratory, and administrative support activities.

The inpatient unit consists of eight beds in two double rooms and four single rooms. All have private restrooms, and one has a private shower.

The outpatient area consists of 12 rooms. Of these, two are general purpose outpatient rooms with beds and private bathrooms, one is an examination/minor procedure room, and one is designated as an interview room. Other rooms on the outpatient wing include a DXA room, a room equipped for neurological testing, dental studies, transcranial magnetic stimulation studies, and a syncope and falls-in-the-elderly laboratory.

The sample processing laboratory service processes samples for analysis at various laboratories, including the investigator's own lab if requested. Point of care testing is done under the hospital's CLIA certification. The laboratory is an access-restricted area where all samples are tracked to maintain chain of custody. Samples are stored at room temperature or in a monitored and alarmed refrigerator, -20 C freezer, or -80 C freezer short term. Access to long term use of -80 C freezers is available.

Access to administrative space includes a conference room, investigator's resource room (an office space for investigators to use while their participant's visit is occurring on the CRC), and use of the statistical programs on three computers located near the statistician's office.

Nursing at HCCRC at BIDMC provides comprehensive care, assessment, and teaching to research participants on the unit and throughout BIDMC as requested. Working collaboratively with the investigator, nurses develop standardized study-specific worksheets, orders, and lab processing instructions to enhance the consistency of data collection. Nurses also work in tandem with staff from other units where research is occurring, to provide a high quality experience for participants and investigators.

The HCCRC at BIDMC has an active Metabolism & Nutrition Research unit with expertise in body composition measurement, bone density, and metabolic testing. Located on the outpatient unit is a metabolic kitchen for preparation of nutrient-controlled meals as well as study-specific testing meals. The Metabolism & Nutrition Research unit also provides state-of-the-art nutrition computing facilities with programs for nutrient analysis, semi-quantitative food frequency analysis, and design and specification of research diets. Services include DXA, anthropometric measurement, indirect calorimetry, weighed meals, diet design, nutrient analysis, nutrition counseling, and education.

More information is available on the BIDMC Clinical Research Center page.

HCCRC at BIDMC Contacts:

CRC Director
Janet Mullington, PhD
Associate CRC Director/MRO
Jody Dushay, MD
Administrative Director
Michelle Beck, MBA
Interim Nurse Director
Mona Lauture, RN
Metabolism & Nutrition Research Director
Joanna Radziejowska, MS, RD, LDN
CRC Front Desk
CRC Sample Processing Laboratory

Boston Children's Hospital

The Harvard Catalyst Clinical Research Center (HCCRC) at Boston Children's Hospital (BCH)/CTSU is an eight-bed unit centrally located within the main building of Boston Children's Hospital on Pavilion 6, and is organized to support the management of children participating in clinical research. The HCCRC at BCH offers over 5,000 square feet of ambulatory/outpatient space, and is adjacent to the inpatient research space, as well as part of the CAT/CR program located in an adjoining building. The outpatient unit has four private exam rooms, three consult rooms, and one special treatment testing room, as well as a metabolic kitchen. The research nurses of the HCCRC at BCH are experienced pediatric research RNs, CPR certified, proficient with IV insertion and maintenance, and experienced with timely collection and bedside processing of blood, urine, and other body samples.

The HCCRC at BCH's Metabolism & Nutrition Research unit has a research dietitian on staff who is experienced with developing/planning meals for research studies. The Center has its own metabolic kitchen to accommodate feeding studies and individual weighed meals. The research dietitians also perform anthropometry, bioelectric impedance analysis, indirect calorimetry, dietary analysis, air displacement plethysmography (BodPod), and nutrition education and/or counseling.

The HCCRC at BCH offers investigators the following research equipment: a Hologic Model-A Discovery Dual Energy X-ray Absorptiometry machine for measurement of bone density and/or body composition, a BIA for body composition evaluation, a portable ultrasound for measurement of bone density, and an Orthometrix model XCT 3000 peripheral quantitative computed tomography (pQCT) scanner to assess bone density.

In addition to the onsite processing laboratory, the HCCRC at BCH has both a processing and short-term storage laboratory (200 sq. ft) located next to and above the Children's Hospital Clinical Laboratories.

More information is available on the BCH Clinical Research Center page.

HCCRC at BCH Contacts:

Interim CRC Director
David Williams, MD
Interim Administrative Director
Judy Fleming
Nurse Director
Lucinda Williams, MSN, RN, PNP, NE-BC
Metabolism & Nutrition Research Director
Nicolle Quinn, MS, RD, LDN
Medical Research Officer
Stavroula Osganian
CRC Front Desk

Brigham and Women's Hospital

The Harvard Catalyst Clinical Research Center (HCCRC) at Brigham and Women's Hospital (BWH)'s 6,000 square foot Inpatient Unit is located on the ninth floor of the main bed tower. The facility is divided into two functional areas. The Intensive Physiologic Monitoring Unit consists of five suites constructed to carry out studies in which nearly all environmental cues can be controlled. Each suite is constructed on an independent "floating" cement floor platform and is self-contained, soundproof, lightproof, and specifically designed with an anteroom for added temporal isolation. This facility also contains a highly sophisticated computer system to control and monitor many environmental factors (light, temperature, humidity, sound) and physiologic functions (blood, saliva, and urine sampling, EEG/sleep recording, neurobehavioral performance testing). The second area is a Standard Bed Unit consisting of six beds in private rooms, two of which are double-size rooms adding sound attenuation (including double entry doors in two rooms) with precise light control, sleep recording and video monitoring equipment to enable environmental isolation studies to be conducted.

The HCCRC at BWH's Outpatient Unit consists of two outpatient centers, each primarily serving a unique population and providing an integrated network of outpatient units that meet the changing scientific and geographic needs of investigators. The Ambulatory Center for Physiologic Research is located at 221 Longwood Avenue. This is a 3,000 square foot center, which includes a waiting room, four examination rooms, one infusion room, conference area, and a small laboratory/specimen processing area. The Ambulatory Center for Therapeutic and Interventional Research is located in 1,800 sq. ft. on the fourth floor of the original Peter Bent Brigham Hospital in space that is shared with the Clinical Trials Center (CTC) and Out-patient Infusion Center. This space includes a waiting room, four examination rooms, and a small laboratory/specimen processing area.

The HCCRC at BWH's Metabolism & Nutrition Research unit consists of two metabolic research kitchens and includes a patient dining area for feeding studies. These two kitchens are designed to enhance resources to support major, multi-center feeding studies. Expertise for the design, implementation, and evaluation of feeding studies has been fine-tuned by BWH research dietitians.

More information is available on the BWH Center for Clinical Investigation page.

HCCRC at BWH Contacts:

CRC Director
Shalender Bhasin, M.B., B.S.
Associate CRC Director/MRO
Gail Adler, MD, PhD
Associate CRC Director
Richard Parad
Administrative Director
Yemi Talabi-Oates
Nurse Director
Sheila Driscoll, RN, MSN
Nutrition Director
Leigh Keating, MS, RD
CRC Scheduling Desk

Massachusetts General Hospital

The Harvard Catalyst Clinical Research Center (HCCRC) at Massachusetts General Hospital (MGH) Inpatient Unit occupies ~6,500 sq. ft. on the 13th floor of the White building. There are five inpatient rooms, including a negative pressure room. In addition, one room is fully equipped for sleep studies with continuous EEG monitoring and blood drawing. The White 13 Clinical Research Center (CRC) is certified for IV conscious sedation.

The HCCRC at MGH Outpatient Unit consists of seven chairs. The inpatient rooms are also available for outpatient visits as needed, providing increased flexibility to accommodate longer, more complicated outpatient visits.

The HCCRC at MGH at the Charlestown Navy Yard (CNY) satellite is an outpatient-only unit and includes five chairs, an exercise treadmill, a metabolic kitchen, and a processing lab. CNY investigators have access to physiological monitoring equipment in the MRI bays. The CRC nurses are trained to perform arterial line blood draws in the MRI.

Nurse Practitioners are available to assist investigators as needed, i.e. signing orders for PhD investigators, and completing admissions, discharges, and monitoring of participants while on the unit. Nurses are available to perform off-unit visits and to support clinical research activity in other areas of the institution and in the community.

More information is available on the MGH Clinical Research Center page.

HCCRC at MGH Contacts:

CRC Director
David Nathan, MD
Associate CRC Director, Pediatrics
Madhusmita Misra, MD/MRO
Administrative Director
Edwin Andrews, MPA
Nurse Director
Kathryn Hall, MS, RNCS, ANP-BC
Metabolism & Nutrition Research Director
Ellen Anderson, MS, RD, LDN
CRC Front Desk

Massachusetts Institute of Technology

The Harvard Catalyst Clinical Research Center (HCCRC) at Massachusetts Institute of Technology (MIT) serves as an ambulatory clinical research center by providing facilities and resources (nursing, psycho-educational evaluation, and statistical) for human subject-oriented investigators to carry out high-quality clinical research. It also serves an educational mission for the MIT community by training investigators at every stage of their careers. The HCCRC at MIT promotes translational research between leading scientists and physicians from MIT and other institutions, and advances patient care by fostering innovative, high-impact ideas and technologies into biomedical treatments. In particular, the MIT center aims to support the rapid translation of outstanding basic science and engineering research at MIT into clinical research aimed at improving health.

The HCCRC at MIT includes a biomedical research suite complete with private clinical monitoring, data acquisition, and lab processing areas, in addition to behavioral testing rooms, and testing observation rooms. The clinical research staff offers support and translational research expertise for all aspects of behavioral and biomedical human research studies, including advanced behavioral and neuropsychological testing, physical assessment, anthropometric measurements, clinical monitoring, and other protocol-specific needs for research involving adults and children.

Further, the MIT center, located outside of a hospital, aims to enhance community outreach for the MIT-Harvard Catalyst research community.

More information is available on the MIT Clinical Research Center page.

HCCRC at MIT Contacts:

CRC Director
John Gabrieli, PhD
Associate CRC Director
Ravi Thadhani, MD, MPH
Assistant CRC Director
Margaret Kjelgaard
Nurse Director
Catherine Ricciardi, RN, DNP(c)
CRC Front Desk

The HCCRC Sites* offer the following Services:

Automated BP/HR/O2 Sat/RR/ECG X X X
Anthropometry X X X X
Bioelectrical Impedance Analysis X X X X
BodPod X
Calorimeter X X X X
Centrifuge (refrigerated) X X X X
Centrifuge (room temp.) X X X X
Cycle ergometer X
Dental chair and periotron X
Food record analysis X X X X
Glucometer X X X X
Inpatient Unit X X X X
Meal/Snack Preparation X X X X
Medical Research Officer X X X X
Metabolism & Nutrition Research (MNR) X X X X
Nurse Practioner, Family X X
Nurse Practioner, other X X X
Nursing Research X X X X
"Off-unit" research support X X X X
Outpatient Rooms X X X X
Pediatric and/or neonatal research X X X X
Phlebotomist X X X
Physio equipment X X
Psychometrician X
Research Study Coordinator/Project Management services X X X
Specialized physiological monitoring X X
Specimen processing X X X X
Specimen storage X X X
Syringe infusion X X X X
Temperature monitor X
Treadmill X
Ultrasound Device X
Vitaport X

*Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, and Massachusetts General Hospital