Providing statistical expertise for clinical & translational investigators. Biostatistics Program

Program News

Grants

Congratulations to Eden Evins, MD, MPH, on the approved funding of the large pragmatic trial, "Dissemination of Effective Smoking Cessation Treatment to Smokers with Serious Mental Illness." Harvard Catalyst consultant David Schoenfeld, PhD, worked closely with Evins and her collaborators, and additionally enlisted the help of Ken Kleinman, ScD. Read more about this grant.

Congratulations to Xinhui Wang and co-investigators Steven Jay Isakoff, MD, PhD, and Marielle Scherrer-Crosbie, MD, PhD, on the funding of their R21 grant. This grant will focus on "Improving Radiation Therapy for Pancreatic Cancer." Harvard Catalyst consultants Dianne Finkelstein, PhD, and Hui Zheng, PhD, assisted with this successful submission. Read more about this grant.

Papers and Awards

Congratulations to Jennifer Scott, MD, MBA, MPH, Director of the Global and Community Health Program at Beth Israel Deaconess Medical Center, on being awarded a Burke Global Health Fellowship. With this fellowship, Jennifer will focus on the development of an instrument to assess sexual violence-related stigma. Harvard Catalyst consultant Michele Hacker, ScD, assisted Jennifer with this application. Read more about this award.

Archived News

Grants

Congratulations to Thomas VanDyke, DDS, PhD, Chair of the Department of Applied Oral Sciences at Forsyth Institute, Vice President of Clinical and Translational Research, and Lecturer at Harvard Medical School, on the full funding of his R01 grant. This grant will explore the mechanism of action of resolvins in a mouse model. Harvard Catalyst consultant Jacqueline Starr, MS, MPH, PhD, helped Thomas and the investigators design the study and perform power calculations. Dr. Starr wrote the grant sections on statistical analysis and sample size justification. Read more about this grant.

Congratulations to Anthony Lembo, MD, Associate Professor at Harvard Medical School, on the full funding of his R01 grant. The grant will examine the efficacy of open-label placebo, double-blind placebo, and peppermint oil in IBS. Harvard Catalyst consultant Roger Davis, ScD, assisted Anthony with this submission. Read more about this grant.

Congratulations to Joren Madsen, MD, DPhil, Director of the MGH Transplant Center, on the full funding of his P01 grant. The grant will explore new approaches to cardiothoratic tolerance induction. Harvard Catalyst consultant Doug Hayden, PhD, assisted Joren with this submission. Read more about this grant.

Congratulations to Ashwin Dharmadhikari, MD, Associate Physician in the Division of Global Health Equity and in the Division of Pulmonary and Critical Care Medicine at Brigham and Women's Hospital, on the full funding of his R01 grant. This grant will focus on finding and treating unsuspected and resistant TB to reduce hospital transmission. Harvard Catalyst consultant Shelley Hurwitz assisted Ashwin with this susbmission. Read more about this grant.

Congratulations to Tal Kenet, PhD, Instructor in Neurology at Massachusetts General Hospital, on the full funding of her R01 grant. The grant will explore the functional connectivity substrates of social and non-social deficits in ASD. Harvard Catalyst consultant Mark Vangel, PhD, assisted Tal with this submission. Read more about this grant.

We are pleased to announce that Caterina Mainero, MD, PhD, Assistant Professor of Radiology at Harvard Medical School, has received full funding for her R01 grant. This grant will look at the cortical mechanisms of disease progression in early multiple sclerosis. Harvard consultant Mark Vangel, PhD, assisted Caterina with this submission. Read more about this grant.

Congratulations to Benjamin Humphreys, MD, PhD, Associate Professor at Harvard Medical School, and Director of the Onco-Nephrology Program at the Dana-Farber Cancer Institute, on receiving full funding for his U01 grant. This grant will examine novel human biomarkers of kidney fibrosis. Harvard consultant Shelley Hurwitz assisted Benjamin with this submission. Read more about this grant.

Congratulations to Dara Manoach, PhD, Associate Professor of Psychology at Harvard Medical School, on the full funding of her R01 grant. The grant will look at sleep-dependent memory processing in schizophrenia. Harvard Catalyst consultant Mark Vangel, PhD, assisted Dara with this submission. Read more about this grant.

We are pleased to announce that E. Antonio Chiocca, MD, PhD, FAANS, Chairman of the Department of Neurosurgery at Brigham and Women's Hospital, has received full funding for his R01 grant. This grant will explore novel anti-invasive and anti-angiogenic drugs for malignant gliomas. Harvard consultant Shelley Hurwitz, PhD, worked with Dr. Chiocca on this grant submission. Read more about this grant.

Congratulations to David Mooney, PhD, Robert P. Pinkas Family Professor of Bioengineering at the Wyss Institute for Biologically Inspired Engineering at Harvard University, on receiving the Michelson grant. This grant will examine infection-mimicking biomaterials for vaccination against gonadotropin releasing hormone. Harvard consultant Rebecca Betensky, PhD, provided justification for the sample size proposed for the studies in the grant proposal and formulated a statistical analysis plan. Read more about this grant.

Congratulations to Brady Roscoe, MD, PhD, instructor at Beth Israel Deaconess Medical Center, on the full funding of his K23 grant. The grant will look at longitudinal imaging studies in bipolar disorder. Harvard Catalyst biostatistical consultant Caitlin Ravichandran, PhD, helped Brady with the analysis of some pilot and illustrative data for the grant. Read more about this grant.

We are pleased to announce that Misra Madhusmita, MD, a pediatric endocrinologist at Massachusetts General Hospital, has received full funding for her R01 grant. This grant will explore homeostatic and hedonic food motivation underlying eating disorder trajectories. Harvard Catalyst biostatistical consultant David Schoenfeld, PhD, helped Misra with the design of the study endpoints and sample size considerations. Read more about this grant.

Congratulations to Bruce Rosen, MD, PhD, professor at Massachusetts General Hospital, on the full funding of his P01 grant. The grant will look at neuroimaging acupuncture effects on brain activity in chronic low back pain. Harvard Catalyst biostatistical consultant Mark Vangel, PhD, helped Bruce with this submission. Read more about this grant.

We are pleased to announce that Ann Shinn, MD, a psychiatrist at McLean Hospital, has received full funding for her K23 grant. The grant will explore auditory speech and cognitive networks in hallucinations across the psychosis spectrum. Harvard Catalyst biostatistical consultant Mark Vangel, PhD, helped Shinn recalculate power based on preliminary data, refine her scientific hypotheses to minimize penalties associated with multiple comparisons, and guided her through her data analysis. Read more about this grant.

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Papers and Awards

Congratulations to Madhu Mazumdar, PhD; Shari Messinger, PhD; Dianne M. Finkelstein, PhD; Judith D. Goldberg, ScD; Christopher J. Lindsell, PhD; Sally C. Morton, PhD; Brad H. Pollock, MPH, PhD; Mohammad H. Rahbar, PhD; Leah J. Welty, PhD; Robert A. Parker, ScD; and the Biostatistics, Epidemiology, and Research Design (BERD) Key Function Committee of the Clinical and Translational Science (CTSA) Consortium, on the publication of their paper "Evaluating Scientists Collaborating in Team-Based Research: A Proposed Framework" in Academic Medicine. Harvard Catalyst biostatistical consultant Dianne Finkelstein is a co-author. Read more about this paper.

Congratulations to Suzanne Bertisch, MD, of Beth Israel Deaconess Medical Center, on being awarded the American Sleep Medicine Foundation Junior Research Award. Suzanne's project will focus on sleep duration and sleep disturbance as a trigger of migraine. Harvard Catalyst biostatistical consultant Murray Mittleman is a co-author.

Congratulations to Bick J, Zhu, T, Stamoulis, C, Fox, NA, Zeanah, C, Nelson CA, on the publication of the paper "Effect of Early Institutionalization and Foster Care on Long-term White Matter Development: A Randomized Clinical Trial," in the Journal of the Ameircan Medical Association. Harvard Catalyst biostatistical consultant Caterina Stamoulis is a co-author. Read more about this paper.

Congratulations to A. Eden Evins, MD, associate professor at Massachusetts General Hospital; Corinne Cather, PhD, assistant professor at Massachusetts General Hospital; Janey S. A. Pratt, MD, assistant professor at Massachusetts General Hospital; Gladys Pachas, MD, instructor at Massachusetts General Hospital; Suzanne Hoeppner, PhD, instructor at Massachusetts General Hospital; Donald Goff, MD, associate professor at Massachusetts General Hospital; Eric Achtyes, MD, chair of the Department of Psychiatry and Behavioral Medicine at Michigan State University; and David Schoenfeld, PhD, professor at Harvard T.H. Chan School of Public Health, on the publication of the paper "Maintenance treatment with varenicline for smoking cessation in patients with schizophrenia and bipolar disorder: a randomized clinical trial," in the Journal of the American Medical Association. Harvard Catalyst biostatistical consultant David Schoenfeld is a co-author. Read more about this paper.

Congratulations to Stephen Huang, MD, director of the Thyroid Program at Boston Children's Hospital, on the publication of "Thyroid hormone inactivation in gastrointestinal stromal tumors" in the New England Medical Journal. Harvard Catalyst biostatistical consultant Henry Feldman, MD, a co-author, guided Huang in obtaining and implementing statistical software for analysis of cell-culture experiments; confirmed and helped interpret results of one-factor comparisons; performed and interpreted additional, more advanced analyses, including two-factor analysis of variance and non-parametric alternatives; and assisted in phrasing results and devising graphical presentation for the manuscript. Read more about this paper.

Congratulations to Omar Khwaja, MD, a neurologist at Boston Children's Hospital, on the publication of the paper "Safety, pharmacokinetcs, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome" in Proceedings of the National Academy of Sciences. Harvard Catalyst biostatistical consultants Kush Kapur, PhD, and Matt Gregas, PhD, both co-authors, contributed substantially to the design of the study; devised and performed statistical analyses suited to the small sample, including parametric and non-parametric tests and random intercept models; and provided appropriate interpretation for the manuscript. Read more about this paper.

Congratulations to Nathalie Goletiani, MD, instructor at McLean Hospital, on being awarded the Zinberg fellowship and the Livingston Award. Goletiani's work focuses on sex differences in understanding the neurobiology of addictive disorders and the development of novel, natural, and more specific treatment strategies. Harvard Catalyst biostatistical consultant David Schoenfeld, PhD, guided Goletiani through her work, helping her articulate her hypothesis more clearly, and making its outcome more realistic in statistical terms.

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