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Events in June 2012

  • June 7, 2012

    arrow-rightThe Effect of Targeting Activin Receptor Type-IIB Signaling

    Time: 12:00 PM - 1:00 PM

    Location: Seminar Room A, 245 First St., 17th floor, Cambridge, 02142

    Speaker: Jennifer L. Lachey, PhD

    Associate Director, Preclinical Pharmacology

    Acceleron Pharma

     

    Summary : The activin receptor type IIB (ActRIIB) is a signaling receptor for multiple TGF? superfamily ligands including activins A and B and myostatin.  These ligands have been implicated in the development and homeostasis of a variety of different tissue types.  For example, myostatin has been characterized as a potent inhibitor of muscle development which also regulates adipose and bone mass.  Previous studies in normal animals demonstrated that inhibition of ActRIIB signaling promotes muscle and bone mass gain while decreasing fat mass. ACE-031 is an ActRIIB-IgG fusion protein that acts as a soluble decoy receptor and binds myostatin and other high-affinity ActRIIB ligands, blocking their signaling through endogenous receptors. Results from non-clinical studies and two phase 1 clinical studies demonstrate that ACE-031 is generally well-tolerated and has rapid and sustained effects on muscle, fat and bone. These results support further studies of ACE-031 in neuromuscular diseases to improve muscle mass, strength, and function.

    For more information or to register, please contact Pam Quattrocchi (email, 617-892-8604)

  • June 7, 2012

    arrow-rightNetwork Science in Biology and Medicine Symposium

    Time: 4:00 PM - 7:00 PM

    Location: Joseph B. Martin Conference Center, Amphitheater, 77 Avenue Louis Pasteur, Boston, MA 02115

    The Network Science in Biology and Medicine Symposium will offer an introduction to a rapidly emerging field that combines systems biology and network science by focusing on the identification and investigation of networks of interacting molecular and cellular components. When integrated into biomedical research, network medicine has the potential to transform investigations of disease etiology, diagnosis, and treatment.

    This symposium will include presentations by four of the leading investigators in the field – Albert-Laszio Barabasi, PhD; Roy Kishony, PhD; Joseph Loscalzo, MD, PhD; and Peter Sorger, PhD. Topics presented will include the role, identification, and behavior of networks in biology and disease; the integration of multiple types of -omics data into perturbed, dynamic networks as a paradigm for understanding disease expression and course; and systems pharmacology approaches for the development and evaluation of effective therapies of complex disease.

    Presentations will be followed by a reception to foster continued discussion.

    This event will be co-chaired by Joseph Loscalzo, MD, PhD and Marc Kirschner, PhD.

    Please register by May 21, 2012.

    Please E-mail us with any questions

  • June 11, 2012

    arrow-rightTMJ Pain Not Just Symptom, but Cause of TMJ Disorders

    Time: 12:00 PM - 1:00 PM

    Location: Seminar Room A, 245 First St., 17th floor, Cambridge, 02142

    Speaker:              Stephanos Kyrkanides, DDS, MS, PhD

    Professor & Department Chairman

    Department of Children’s Dentistry

    Stony Brook University Health Science Center

     

    Summary : We will review the prevalence of  TMJ Disorders in children and their effects on craniofacial growth and development. In addition to the direct effects on mandibular growth, TMJ pain appears, based on cutting edge research, to also affect cranial base development and consequently midface growth. TMJ Disorders and the attendant pain is therefore very important in children as it can affect the child's craniofacial growth and development. Novel therapies for the management of pain will also be presented that not only reduce the pain from the TMJ but also normalize postnatal craniofacial development in children.

    For more information or to register, please contact Pam Quattrocchi (email, 617-892-8604)

  • June 27, 2012

    arrow-rightAn Overview of REDCap: A Free, Web-based Data-Management & Survey Tool

    Time: 12:30 PM - 2:00 PM

    Location: Karp Building, 7th Floor Conf Room, Children’s Hospital Boston, 300 Longwood Avenue, Boston 02115

    Come learn about REDCap and REDCap Survey, two free, web-based data management tools available to Harvard investigators through the Harvard-affiliated academic health care centers. Using REDCap, investigators can create and design projects using:

    • A web browser-based Online Form Editor; and/or
    • An offline method by constructing and uploading a “data dictionary” template file in Microsoft Excel.

    Christian Botte, a Harvard Catalyst electronic data capture (EDC) support specialist based at Beth Israel Deaconess Medical Center, will present information sessions at Children’s Hospital Boston on how to utilize the tools to build and manage online databases and surveys.

    REDCap provides automated export procedures for seamless data downloads to Excel and common statistical packages (SPSS, SAS, Stata, R), built-in project calendars, a scheduling module, ad hoc reporting tools, and advanced features including branching logic, file uploading, field validations, and calculations.

    Presented by the Clinical Research Program Education Core at Children’s Hospital Boston, in collaboration with Harvard Catalyst.

    Registration is required in order to attend any of these sessions. For more information, contact Harvard Catalyst EDC support specialist Christian Botte (E-mail, 617-754-8828). To register, click here.

    Harvard Catalyst offers cross-institutional support for investigators interested in or currently using REDCap, including explanations of the features of REDCap and REDCap survey (a similar application for creating and managing surveys), a set of FAQs, user guides, links to institutional REDCap systems, and a Harvard Catalyst EDC support team. To learn more, visit Harvard Catalyst’s REDCap page.