New research by scientists at Dana-Farber Cancer Institute and Brigham and Women’s Hospital found that genetic profiling can guide stem cell transplantation for patients with myelodysplastic syndrome (MDS). MDS are a group of diverse bone marrow disorders in which the bone marrow does not produce enough healthy blood cells. Stem cell transplantation is the only curative therapy for MDS, but many patients die due to relapse or complications from the transplantation. This study sought to discover whether genetic mutations in MDS patients’ blood cells, which are closely related to the course the disease takes, can also be used to predict how patients will fare following a donor stem cell transplant. Read the full Dana-Farber news article.
A new study from clinician-researchers at Harvard Medical School and Beth Israel Deaconess Medical Center found that hospital-led interventions over a seven-year period were associated with a significant reduction in the hospital’s cesarean delivery rate. Researchers found that during the intervention period the NTSV cesarean rate decreased from 34.9 percent to 21.2 percent, below the U.S. Department of Health and Human Services’ recommended target rate of 23.9 percent. Read the full HMS News story.
SMART IRB, a new platform to enable single IRB review for multisite studies, has signed over 140 institutions including all 64 CTSA hubs. As part of the pilot phase of the IRB Reliance system, researchers have the opportunity to gain early access, provide input to guide future development, and ensure SMART IRB meets the needs of the nation. Studies must involve two to five sites that hold a federal-wide assurance (FWA), not have IRB review or received approval, and include a PI with experience conducting multisite research. For more information, please contact us.
The current research landscape presents a variety of challenges for multisite pediatric research. The purpose of this year's day-long symposium is to bring together outstanding speakers from across the nation with Harvard's Child Health Research community to discuss key areas across the clinical and translational spectrum in relation to facilitating the success of multisite pediatric trials. See Harvard Catalyst Events below for registration information.
Are you interested in supporting the development of the next generation of clinical and translational scientists? The Harvard Catalyst Program for Faculty Development Diversity Inclusion is seeking faculty mentors from HMS and the affiliated hospitals for the Visiting Research Internship Program (VRIP) and the Summer Clinical and Translational Research Program (SCTRP) summer internship programs. Read the HMS News article spotlighting VRIP, and for more information, please contact Carol Martin.
Harvard Catalyst's Reactor Program creates funding opportunities and a supportive environment that encourages clinical researchers to push their ideas in new directions and ultimately, successfully translate them into solutions that benefit patients. Recently, Reactor awarded $50,000 each to eight pilot awardees, and provided access to the Harvard Center for Biological Imaging (HCBI) for the use of Zeiss microscopes, and/or to the Center for Nanoscale Systems, which offers electron microscopy, nanoscale fabrication, and nanoscale analysis capabilities.
HARVARD CATALYST EDUCATION
In this four-day, one-stop shop for translational biomarker research, participants will learn about the entire spectrum of biomarker science, from discovery to evaluation and commercialization. Read the HMS News article on this course, and visit the website to apply.
This online course offers an in-depth introduction to the grant-writing process, including strategies shared firsthand by biomedical researchers who have successfully received funding from various grant sources available to researchers.
This three-day, hands-on workshop introduces participants to the basics of R and RStudio and their application to differential gene expression analysis on RNA-Seq count data.
Do you have an idea for a new or improved medical device, want to understand the medical device space, or hope to have a career in which you develop or use medical devices? This two-day course includes case discussions and interactive panel sessions that address the development process from determining clinical need through post-market surveillance.
This online course provides an overview of the NIH grant submission process, with a particular focus on the R01 and K career development grants. Instructors for the course include researchers who have successfully applied for NIH funding and researchers who have served on study sections.
This two-day course assists emerging clinical and translational investigators navigate the complexities of the mentoring dynamic. With an emphasis on the perspective of the mentee, this course explores the lifecycle of mentoring relationships through the presentation of case studies, lectures, and interactive sessions. Each session addresses critical issues such as expectations and responsibilities, pitfalls and challenges, communication, and career development.
HARVARD CATALYST EVENTS
Mark Goldberg, MD, will lead this interactive seminar on the need for well-integrated, multidisciplinary, pre-clinical, and clinical development teams with complementary fields of expertise to improve the efficiency and likelihood of success of a drug development program. The different steps and phases of clinical development as well as the integration of input from regulatory authorities will be discussed. This event is sponsored by the Skills Development Center (SDC) at the Boston Biomedical Innovation Center (B-BIC).
Murray Mittleman, PhD, professor of epidemiology, Harvard T.H. Chan School of Public Health, will lead the March meeting of the Harvard Catalyst Biostatistics Journal Club. March 16, 12:30-1:30pm, Harvard T.H. Chan School of Public Health, Room 2-426. Please contact Jai Vartikar for call-in information.
In this interactive seminar, Vincent J. Carey, PhD, will briefly sketch some key concepts from the “Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results” workshop from the National Academy of Sciences and the National Science Foundation, and then review a number of his own efforts to implement reproducible research principles in cancer genomics, vaccine evaluation, and statistical software design. After the talk, Carey will guide the audience in mobilizing github, Rstudio, and Travis CI to demonstrate what is involved in embedding reproducibility practice in daily work. March 30, 2:30-4:00pm, Dana 1620, DFCI. Attendees interested in hands-on experience should have a github account and bring a laptop with a recent version of Rstudio. Talk materials and links to relevant resources are available now. For more information, please contact us.
The current research landscape presents a variety of challenges for multisite pediatric research. The purpose of this year's day-long symposium is to bring together outstanding speakers from across the nation with Harvard's Child Health Research community to discuss key areas across the clinical and translational spectrum in relation to facilitating the success of multisite pediatric trials. April 4, 8:00am-4:30pm, Joseph B. Martin Conference Center, Rotunda, HMS. Please visit the website to register by March 28.
This full-day interactive seminar sponsored by the Skills Development Center (SDC) at the Boston Biomedical Innovation Center (B-BIC) explores the path by which a discovery becomes transformed through the stages of invention, commercialization, and large-scale deployment. Discussion topics include factors that influence commercial viability, various revenue models and pricing structures, and how the timing of a product launch can impact market success.
In a perfect world, the development and launch of new medical device products happens on schedule, under budget, with smooth review and approval from FDA, and goes on to hit record sales. In reality, the road is long and has many unexpected turns. This full-day offering from the Skills Development Center (SDC) at the Boston Biomedical Innovation Center (B-BIC) explores the factors that can affect the success of innovations.
OTHER COURSES & EVENTS
March 21, 2017
Shawn Rangel, MD, MSCE, will lead the latest seminar in the Harvard Surgical HSR Speaker Series with a presentation entitled “The Past, Present & Future of Pediatric National Quality Improvement Program (NSQIP): Evolution From a Safety Registry to Comprehensive Comparative Performance Platform.”
March 29, 2017
Karl Deisseroth, MD, PhD, the D.H. Chen Professor of Bioengineering and of Psychiatry and Behavioral Sciences at Stanford University, and an investigator at the Howard Hughes Medical Institute, will give the BCH 24th Annual Enders Lecture. His laboratory created and developed both optogenetics, a technology for precisely controlling millisecond-scale activity patterns in specific cell types, and CLARITY, a technology for creating composites of biological molecules in tissue covalently linked to polymer hydrogels. March 29, 12:00pm, Folkman Auditorium, BCH. Please email for more information.
March 31, 2017
The 2017 Visiting Scholar for the Center of Excellence for Delirium in Aging: Research, Training, and Educational Enhancement (CEDARTREE), is Brad Dickerson, MD, director, Frontotemporal Disorders Unit and Neuroimaging Lab, MGH. Dickerson will give a presentation entitled "Large-Scale Brain Systems Subserving Cognitive and Affective Function: Imaging Biomarkers of Vulnerability and Resilience." March 31, 8:30-9:30am, Synagogue, (Third Floor) Hebrew SeniorLife. For directions, please visit the website. To RSVP, please contact Sarah Dowal.
April 4, 2017
Join researchers, clinicians, and members of the medical community for a discussion on this year’s topic, “Developmental and Stem Cell Biology of the Alimentary Tract.” To register and see the list of speakers, please visit the website.
April 6-7, 2017
This two-day, single-track conference facilitates conversations among experts about emerging ethical issues raised in the use of reproductive technologies. To register, please visit the website.
April 7, 2017
The 2017 symposium "Contemporary Statistical Challenges in Clinical Research", is a tribute to Richard Gelber on his 70th birthday. Please visit the website to register.
April 24-28, 2017
Develop the skills to implement radiation protection programs in biotechnology, university, hospital, medical laboratory, or commercial settings. Participants have the opportunity to gain 40 hours of training required for an RSO and receive a DOT and IATA Class 7 Radioactive Materials Shipping Certification.
May 31-June 2, 2017
Whether the Affordable Care Act is repealed, replaced, or re-worked, healthcare professionals need to anticipate how health reform will impact their organizations, employees, and patients. Learn from the nation’s top experts on how to prepare for the future of health policy under the new administration.